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Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia.
This study attempts to determine the primary actions of 5-azacytidine (5-azaCR) on L1210 leukemia. This agent was cytotoxic toward L1210 cells growing in culture with 50 and 90% inhibition dose… Expand
Determination of reducing sugar with improved precision.
Abstract The neocuproine test as described by Brown (4) has been modified to include the range of 5 to 125 μg of glucose. The replacement of the tartrate chelating agent by glycine reduces the value… Expand
Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
Ecteinascidins 729, 743, 745, 759A, 759B, and 770, tris(tetrahydroisoquinolines) with potent in vivo antitumor activity, have been isolated from the colonial tunicate Ecteinascidia turbinata, and… Expand
Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats.
- R. Wine, L. Li, L. Barnes, D. K. Gulati, R. Chapin
- Biology, Medicine
- Environmental health perspectives
- 1 January 1997
The phthalate ester di-n-butylphthalate (DBP) is used extensively in the manufacture of plastics; its reproductive toxicity was tested in rats by the National Toxicology Program's Reproductive… Expand
Cytotoxicity and antitumor activity of carzelesin, a prodrug cyclopropylpyrroloindole analogue.
The cyclopropylpyrroloindole analogues are DNA minor-groove binders containing a cyclopropyl group, which mediates N3-adenine covalent adduct formation in a sequence-selective fashion. Carzelesin… Expand
CC-1065 (NSC 298223), a novel antitumor agent that interacts strongly with double-stranded DNA.
- L. Li, D. Swenson, S. L. Schpok, S. Kuentzel, B. Dayton, W. Krueger
- Biology, Medicine
- Cancer research
- 1 March 1982
CC-1065, a novel antibiotic produced by Streptomyces zelensis, was active against several experimental tumors in vivo and a broad spectrum of human tumor cells in vitro. This report describes its… Expand
Action of camptothecin on mammalian cells in culture.
Summary Camptothecin (CN) is active against several experimental tumors and has also been studied clinically. We report here the effect of CN on L1210 cells and asynchronous and synchronous DON cells… Expand
Mechanism of interaction of CC-1065 (NSC 298223) with DNA.
CC-1065 (NSC 298223), a potent new antitumor antibiotic produced by Streptomyces zelensis, interacts strongly with double-stranded DNA and appears to exert its cytotoxic effects through disruption of… Expand
Quantitative analysis of plasma circulating DNA at diagnosis and during follow-up of breast cancer patients.
The aim of the present project was to quantify the level of plasma DNA in patients with malignant or non-malignant breast diseases and in healthy controls, then investigate whether such measurements… Expand