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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
The low-density lipoprotein receptor–related protein (Lrp)-5 functions as a Wnt coreceptor. Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass phenotype. In vivo and in… Expand
Assessor or assessee: How student learning improves by giving and receiving peer feedback
This study investigated the relationship between the quality of peer assessment and quality of student projects in a technology application course for teacher education students. Expand
Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation
ABSTRACT Mutations in BSCL2 underlie human congenital generalized lipodystrophy. We inactivated Bscl2 in mice to examine the mechanisms whereby absence of Bscl2 leads to adipose tissue loss and… Expand
Protection against Fatty Liver but Normal Adipogenesis in Mice Lacking Adipose Differentiation-Related Protein
ABSTRACT Adipose differentiation-related protein (ADFP; also known as ADRP or adipophilin), is a lipid droplet (LD) protein found in most cells and tissues. ADFP expression is strongly induced in… Expand
Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes
- Han-Qiong Zhang, Xi-feng Zhang, +6 authors W. Shen
- Medicine, Biology
- Molecular Biology Reports
- 1 May 2012
Bisphenol A (BPA) is an estrogenic environmental toxin widely used for the production of plastics. Frequent human exposure to this chemical has been proposed to be a potential public health risk. The… Expand
Deficiency of Adipose Differentiation-Related Protein Impairs Foam Cell Formation and Protects Against Atherosclerosis
Foam cells are a hallmark of atherosclerosis. However, it is unclear whether foam cell formation per se protects against atherosclerosis or fuels it. In this study, we investigated the role of… Expand
Relationship between late‐life depression and life stressors: Large‐scale cross‐sectional study of a representative sample of the Japanese general population
- Tatsuhiko Kaji, K. Mishima, +7 authors M. Uchiyama
- Psychology, Medicine
- Psychiatry and clinical neurosciences
- 1 August 2010
Aim: The purpose of the present study was to clarify the relationship between late‐life depression and daily life stress in a representative sample of 10 969 Japanese subjects.
Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes.
- E. McCall, L. Li, H. Satoh, T. R. Shannon, L. Blatter, D. Bers
- Chemistry, Medicine
- Circulation research
- 1 December 1996
FK-506 binding protein (FKBP) has been reported to be closely associated with the ryanodine receptor in skeletal and cardiac muscle and to modulate sarcoplasmic reticulum (SR) Ca2+ release channel… Expand
Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma.
AIM To establish a model for prognosis assessment of extranodal follicular dendritic cell (FDC) sarcoma. METHODS Nine lesions were examined by routine and molecular approaches. Clinicopathological… Expand
Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway
Oxidative damage plays a critical role in many diseases of the central nervous system. This study was conducted to determine the molecular mechanisms involved in the putative anti-oxidative effects… Expand