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FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.
Akt is a central regulator of cell growth. Its activity can be negatively regulated by the phosphatase PHLPP that specifically dephosphorylates the hydrophobic motif of Akt (Ser473 in Akt1). However,… Expand
Persistent Cell Motion in the Absence of External Signals: A Search Strategy for Eukaryotic Cells
Background Eukaryotic cells are large enough to detect signals and then orient to them by differentiating the signal strength across the length and breadth of the cell. Amoebae, fibroblasts,… Expand
Nuclear factor high‐mobility group box1 mediating the activation of toll‐like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice
One of the challenges surrounding nonalcoholic fatty liver disease (NAFLD) is to discover the mechanisms that underlie the initiation of it. The aim of the present study was to elucidate the effects… Expand
Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products
Recent baby formula milk powder contamination incidents have shown that the classic markers or standards in milk quality control are insufficient in identifying “manipulated” poor-quality milk. In… Expand
The protective role of hydrogen-rich saline in experimental liver injury in mice.
BACKGROUND & AIMS Reactive oxygen species (ROS) are considered to play a prominent causative role in the development of various hepatic disorders. Antioxidants have been effectively demonstrated to… Expand
Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells.
B-cell receptor (BCR) signaling activates a number of intracellular signaling molecules including phospholipase C-gamma2 (PLC-gamma2), which generates membrane diacylglycerol (DAG). DAG recruits both… Expand
The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma.
BACKGROUND/AIMS MicroRNAs are a small non-coding family of genes involved in the regulation of gene expression in a post-transcriptional manner and contribute to cell proliferation, differentiation… Expand
Morphological and molecular evidences for DNA introgression in haploid induction via a high oil inducer CAUHOI in maize
The phenomenon of maternal haploid induction in maize was first described many years ago, but the underlying mechanism is still unclear. In this study, the Stock-6-derived, haploid-inducing line… Expand
Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China
- Dawei Shi, L. Li, +5 authors Guofeng Zhu
- Biology, Medicine
- The Journal of antimicrobial chemotherapy
- 21 July 2011
Objectives To determine the association between embB mutations and drug resistance, and to further investigate the mechanism of embB mutations involved in the development of ethambutol and multidrug… Expand
Carrageenan and its applications in drug delivery.
Carrageenan is a sulphated linear polysaccharide of D-galactose and 3, 6-anhydro-D-galactose obtained by extraction of certain red seaweeds of the Rhodophyceae class. The objective of this review is… Expand