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Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Novel evidence is presented that conversion of naive peripheral CD4+CD25− T cells into anergic/suppressor cells that are CD25+, CD45RB−/low and intracellular CTLA-4+ can be achieved through costimulation with T cell receptors (TCRs) and transforming growth factor β (TGF-β). Expand
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition. Expand
TEAD mediates YAP-dependent gene induction and growth control.
TEAD is revealed as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP, and is required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. Expand
Role of LXRs in control of lipogenesis.
The identification here of a synthetic, nonsteroidal LXR-selective agonist series represented by T0314407 and T0901317 revealed a novel physiological role of LXR, and suggested that the increase in plasma lipids occurs via NXR-mediated induction of the sterol regulatory element-binding protein 1 (SREBP-1) lipogenic program. Expand
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
New insights are provided into the Hippo signaling pathway, elucidating novel phosphorylation-dependent and independent mechanisms of YAP/Yki inhibition by the hippo pathway, new Hippo pathway components, novel YAP target transcription factors and target genes, and the three-dimensional structure of the YAP-TEAD complex, and providing further evidence for the involvement of Y AP and the Hippi pathway in tumorigenesis. Expand
Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination.
China has already reached the national goal of reducing HBsAg prevalence to less than 1% among children under 5 years and has prevented an estimated 16-20 million HBV carriers through hepatitis B vaccination of infants and immunization program should be further strengthened to reach those remaining at highest risk. Expand
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis.
  • S. P. Oh, T. Seki, +8 authors E. Li
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 14 March 2000
The results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis. Expand
TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis
It is established that TIPE2 is an essential negative regulator of TLR and TCR function, and its selective expression in the immune system prevents hyperresponsiveness and maintains immune homeostasis. Expand
Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis.
Through cytoskeleton reorganization, cell detachment activates the Hippo pathway kinases Lats1/2 and leads to YAP phosphorylation and inhibition, providing a novel connection between cell attachment and anoikis through the HippO pathway and have important implications in cancer therapeutics. Expand
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
A key role is shown for IPAF and capase-1 in innate immune responses to the pathogen P. aeruginosa, and it is demonstrated that virulent ExoU-expressing strains of P. Aerug inosa can circumvent this innate immune response. Expand