• Publications
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Engaging neuroscience to advance translational research in brain barrier biology
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood–brain barrier (BBB)Expand
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The gap junction cellular internet: connexin hemichannels enter the signalling limelight.
Cxs (connexins), the protein subunits forming gap junction intercellular communication channels, are transported to the plasma membrane after oligomerizing into hexameric assemblies called connexinExpand
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Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.
BACKGROUND In mammals, oocyte activation at fertilization is thought to be induced by the sperm-specific phospholipase C zeta (PLCzeta). However, it still remains to be conclusively shown thatExpand
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Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles
Functional interaction between neurons and glia is an exciting field that has expanded tremendously during the past decade. Such partnership has multiple impacts on neuronal activity and survival.Expand
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Neurobarrier Coupling in the Brain: A Partner of Neurovascular and Neurometabolic Coupling?
  • L. Leybaert
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism…
  • 1 January 2005
Neurovascular and neurometabolic coupling help the brain to maintain an appropriate energy flow to the neural tissue under conditions of increased neuronal activity. Both coupling phenomena provideExpand
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Mimetic Peptides as Blockers of Connexin Channel-Facilitated Intercellular Communication
There is a dearth of chemical inhibitors of connexin-mediated intercellular communication. The advent of short “designer” connexin mimetic peptides has provided new tools to inhibit connexin channelsExpand
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The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes
In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channelsExpand
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Intracellular calcium changes trigger connexin 32 hemichannel opening
Connexin hemichannels have been proposed as a diffusion pathway for the release of extracellular messengers like ATP and others, based on connexin expression models and inhibition by gap junctionExpand
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Intercellular Ca(2+) waves: mechanisms and function.
Intercellular calcium (Ca(2+)) waves (ICWs) represent the propagation of increases in intracellular Ca(2+) through a syncytium of cells and appear to be a fundamental mechanism for coordinatingExpand
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Paracrine signaling through plasma membrane hemichannels.
Plasma membrane hemichannels composed of connexin (Cx) proteins are essential components of gap junction channels but accumulating evidence suggests functions of hemichannels beyond the communicationExpand
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