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Engaging neuroscience to advance translational research in brain barrier biology
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood–brain barrier (BBB)… Expand
The gap junction cellular internet: connexin hemichannels enter the signalling limelight.
Cxs (connexins), the protein subunits forming gap junction intercellular communication channels, are transported to the plasma membrane after oligomerizing into hexameric assemblies called connexin… Expand
Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.
BACKGROUND In mammals, oocyte activation at fertilization is thought to be induced by the sperm-specific phospholipase C zeta (PLCzeta). However, it still remains to be conclusively shown that… Expand
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles
- C. Giaume, L. Leybaert, Christian C. Naus, Juan C. Sáez
- Biology, Medicine
- Front. Pharmacol.
- 17 July 2013
Functional interaction between neurons and glia is an exciting field that has expanded tremendously during the past decade. Such partnership has multiple impacts on neuronal activity and survival.… Expand
Neurobarrier Coupling in the Brain: A Partner of Neurovascular and Neurometabolic Coupling?
- L. Leybaert
- Biology, Medicine
- Journal of cerebral blood flow and metabolism…
- 1 January 2005
Neurovascular and neurometabolic coupling help the brain to maintain an appropriate energy flow to the neural tissue under conditions of increased neuronal activity. Both coupling phenomena provide… Expand
Mimetic Peptides as Blockers of Connexin Channel-Facilitated Intercellular Communication
There is a dearth of chemical inhibitors of connexin-mediated intercellular communication. The advent of short “designer” connexin mimetic peptides has provided new tools to inhibit connexin channels… Expand
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes
- V. Abudara, J. Bechberger, +6 authors C. Giaume
- Medicine, Biology
- Front. Cell. Neurosci.
- 21 October 2014
In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels… Expand
Intracellular calcium changes trigger connexin 32 hemichannel opening
Connexin hemichannels have been proposed as a diffusion pathway for the release of extracellular messengers like ATP and others, based on connexin expression models and inhibition by gap junction… Expand
Intercellular Ca(2+) waves: mechanisms and function.
Intercellular calcium (Ca(2+)) waves (ICWs) represent the propagation of increases in intracellular Ca(2+) through a syncytium of cells and appear to be a fundamental mechanism for coordinating… Expand
Paracrine signaling through plasma membrane hemichannels.
Plasma membrane hemichannels composed of connexin (Cx) proteins are essential components of gap junction channels but accumulating evidence suggests functions of hemichannels beyond the communication… Expand