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Signal recognition particle RNA localization within the nucleolus differs from the classical sites of ribosome synthesis
The nucleolus is the site of ribosome biosynthesis, but is now known to have other functions as well. In the present study we have investigated how the distribution of signal recognition particleExpand
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Nuclear export of signal recognition particle RNA in mammalian cells.
In mammalian cells the signal recognition particle (SRP) consists of a approximately 300 nucleotide RNA and six proteins. Although the molecular structure and functional cycle of the SRP are bothExpand
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Survival in adults and children with systemic lupus erythematosus: a systematic review and Bayesian meta-analysis of studies from 1950 to 2016
Objective To determine trends in survival among adult and paediatric patients with systemic lupus erythematosus (SLE) from 1950 to the present. Methods We performed a systematic literature review toExpand
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Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa
Background Systemic lupus erythematosus (SLE) is a life-threatening multisystem autoimmune disease that is more severe in patients of African ancestry and children, yet pediatric SLE on the AfricanExpand
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Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.
BACKGROUND Undifferentiated systemic autoinflammatory diseases (USAID) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identifyExpand
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Apartheid and healthcare access for paediatric systemic lupus erythematosus patients in South Africa
South Africa (SA) still faces the legacy of apartheid: the history, politics and economics have a lasting, indelible effect on the health of its people. Here, we discuss the challenges of caring forExpand
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GG-10 Imagine SLE: international multi-site assessment of genetics and inflammation in early onset and familial systemic lupus erythematosus
Background Systemic Lupus Erythematosus (SLE) is a severe, multisystem autoimmune disease. Twin and sibling studies indicate a strong genetic contribution (44–69%) to SLE. Although numerous recentExpand
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A clinical update on paediatric lupus.
Systemic lupus erythematosus in children is a life-threatening chronic disease that is being increasingly recognised. More black African children are being diagnosed and the proportion of malesExpand
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Missed opportunities for timely diagnosis of pediatric lupus in South Africa: a qualitative study
BackgroundSystemic Lupus Erythematosus (SLE) is a serious multisystem autoimmune disease, which is more aggressive in children and people of African descent. In South Africa, pediatric SLE (pSLE)Expand
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Rheumatology capacity building: implementing a rheumatology curriculum for Liberian health-care providers in 2016
Introduction Liberia has no rheumatology providers for the nation’s 4.7 million people. We proposed a short course format rheumatology curriculum to educate Liberian providers as an initial step inExpand
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