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Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues
TLDR
The antiviral data show that the adenovirus DNA polymerase exhibits sensitivity to a relatively broad spectrum of inhibitors and should be studied further as an antiviral target in antiadenovirus drug development programs. Expand
Clinical features and treatment of adenovirus infections
TLDR
Current knowledge on Adenoviruses biology, the clinical features observed in different patient groups and specific immune responses towards Ad infections are updated, and current and future treatment options are reviewed. Expand
Antiviral therapy for adenovirus infections.
TLDR
The mode of action and antiviral data for cidofovir and ribavirin, obtained in cell culture, animal models or patients, are reviewed. Expand
Mouse adenovirus type 1 attachment is not mediated by the coxsackie‐adenovirus receptor
TLDR
The receptor usage of mouse adenovirus type 1 (MAV‐1), which in vivo is characterized by a pronounced endothelial cell tropism, is investigated, and alignment of the fiber knob sequences revealed that amino acid residues, critical for interaction with CAR, are not conserved in the MAV‐ 1 fiber knob. Expand
Mouse Adenovirus Type 1 Infection in SCID Mice: an Experimental Model for Antiviral Therapy of Systemic Adenovirus Infections
TLDR
It is suggested that complete virus clearance during antiviral therapy for disseminated adenovirus infection may require an efficient adaptive immune response from the host. Expand
Genomewide copy number alteration screening of circulating plasma DNA: potential for the detection of incipient tumors
TLDR
Genomewide profiling of cfDNA in apparently healthy individuals enables the detection of incipient hematologic malignancies as well as clonal mosaicism with unknown clinical significance, and demonstrates that cfDNA screening detects CNAs, which are not only derived from peripheral blood, but even more from other tissues. Expand
Interaction between Mouse Adenovirus Type 1 and Cell Surface Heparan Sulfate Proteoglycans
TLDR
It is demonstrated that mouse adenovirus type 1 uses cell surface heparan sulfate proteoglycans (HSPGs) as primary cellular attachment receptor and analysis of the binding of MAV-1 and Ad5 to the NCI-60 panel of different human tumor cell lines revealed the preference of MAv-1 for ovarian carcinoma cells. Expand
Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting
TLDR
Alternative adenovirus serotypes are being explored because several target cells, such as endothelial and smooth muscle cells, are difficult to transduce by Ad5 due to the low expression of the primary coxsackie‐adenovirus receptor (CAR). Expand
Recovery of Humoral Immunity Is Critical for Successful Antiviral Therapy in Disseminated Mouse Adenovirus Type 1 Infection
TLDR
The concomitant use of adenovirus-specific immunoglobulins and antiviral therapy should be considered for transplant patients at risk for severe adenOVirus infections. Expand
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