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Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure.
A working group charged with delineating in broad terms the current base of scientific and medical understanding about the right ventricle and identifying avenues of investigation likely to meaningfully advance knowledge in a clinically useful direction is convened. Expand
Valvular Myofibroblast Activation by Transforming Growth Factor-&bgr;: Implications for Pathological Extracellular Matrix Remodeling in Heart Valve Disease
It is suggested that the activation of contractile myofibroblasts by TGF-&bgr;1 may be a significant first step in promoting alterations to the valve matrix architecture that are evident in valvular heart disease. Expand
A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy
A form of PGC-1α (PGC-1 α4) that results from alternative promoter usage and splicing of the primary transcript is identified that regulates and coordinates factors involved in skeletal muscle hypertrophy. Expand
A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine
Results suggest that IL-1 and fractalkine are endogenous regulators of morphine analgesia and are involved in the increases in pain sensitivity that occur after chronic opiates. Expand
Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse.
Together these data demonstrate that voluntary exercise in mice results in cardiac and skeletal muscle adaptations consistent with endurance exercise. Expand
Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.
The identification of two human skeletal MHC genes as fast IIa and IIx MHC based on pattern of expression and sequence homology with the corresponding rat genes in the 3'-translated and untranslated regions is reported. Expand
Evidence that opioids may have toll-like receptor 4 and MD-2 effects
Evidence is provided that select opioids may non-stereoselectively influence TLR 4 signaling and have behavioral consequences resulting, in part, via TLR4 signaling. Expand
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
Seven separation-of-function mutants of human TPP1 are identified that retain full telomere-capping function in vitro and in vivo, yet are defective in binding human telomerase. Expand
Cells: a laboratory manual
Cells : a laboratory manual , Cells : a laboratory manual , کتابخانه مرکزی دانشگاه علوم پزشکی ایران
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
It is proposed that targeting the production of proinflammatory cytokines by intrathecal IL-10 gene therapy may be a promising therapeutic strategy for the relief of paclitaxel-induced neuropathic pain. Expand