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Cancer incidence and mortality in France over the period 1978-2000.
A striking divergence between incidence and mortality trends is observed for a great number of cancers, and prostate cancer shares with breast cancer the same pattern of a severe increasing incidence and a stable mortality.
Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis
The findings confirm the implication of the cationic trypsinogen gene in HP and highlight allelic diversity associated with this phenotype and show that the pattern of inheritance of HP is probably complex and that other genes may be involved in this genetic disease.
Mutational screening of the cationic trypsinogen gene in a large cohort of subjects with idiopathic chronic pancreatitis
Mutational screening of the entire coding sequence and the intronic/exonic boundaries of the PRSS1 gene in 221 ICP subjects confirmed that HP‐associated PRSS 1 mutations are rare in ICP, and predisposition to pancreatitis by some of them is suspected.
The hereditary pancreatitis gene maps to long arm of chromosome 7.
A large French family from a four-generation kindred with HP has been examined and a genome segregation analysis of highly informative microsatellite markers has been performed, indicating the most likely order for the Hereditary Pancreatitis Gene (HPG) is D7S 640-D 7S 495-D7S 684-D8S 661-D9S 676-D6S 688, with the HP gene situated in the underlined region.
Frequency and risk factors of recurrent pain during refeeding in patients with acute pancreatitis: a multivariate multicentre prospective study of 116 patients.
Pain relapse occurred in one fifth of the patients with acute pancreatitis during oral refeeding and was more common in patients with necrotic pancreatitis and with longer periods of pain.
Experimental aspects of in vitro and in vivo photochemotherapy.
In vivo studies employed the HT 29 tumor model grafted into nude mice and histological examination of these did not reveal any quantitative differences, and the selectivity of in vitro photodynamic reactions and the in vivo effects induced by PRT still remains unclear.
Endoscopic photodynamic therapy with haematoporphyrin derivative in gastroenterology.
Endoscopic photodynamic therapy (PDT) with haematoporphyrin derivative was used in the primary treatment of 69 patients with inoperable gastrointestinal neoplasms. Patients were divided into three
Low dose omeprazole effects on gastric acid secretion in normal man.
Treatment with Om10 has a consistent and long lasting inhibitory action on gastric acidity without statistically significant effect on serum gastrin levels, suggesting that 10 mg Om daily should be sufficient in some duodenal ulcer patients to effectively inhibit gastric Acidity specially when long-term treatment seems to be indicated.
[Prevention of recurrent hemorrhage in patients with cirrhosis. Results of a controlled trial of propranolol versus endoscopic sclerotherapy].
In this trial, no significant difference could be demonstrated between propranolol and endoscopic sclerosis in the prevention of recurrent variceal hemorrhage in alcoholic cirrhotic patients.