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Plaid models for gene expression data
- L. Lazzeroni
Motivated by genetic expression data, we introduce plaid models. These are a form of two-sided cluster analysis that allows clusters to overlap. Plaid models also incorporate additive two way ANOVA… Expand
Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapy.
- G. Sanders, A. Bayoumi, +7 authors D. Owens
- The New England journal of medicine
- 10 February 2005
BACKGROUND The costs, benefits, and cost-effectiveness of screening for human immunodeficiency virus (HIV) in health care settings during the era of highly active antiretroviral therapy (HAART) have… Expand
Genome-Wide Identification of Genes Conferring Resistance to the Anticancer Agents Cisplatin, Oxaliplatin, and Mitomycin C
Cisplatin is a crucial agent in the treatment of many solid tumors, yet many tumors have either acquired or intrinsic resistance to the drug. We have used the homozygous diploid deletion pool of… Expand
A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.
- S. Liggett, J. Mialet-Perez, +15 authors M. Bristow
- Proceedings of the National Academy of Sciences…
Heterogeneity of heart failure (HF) phenotypes indicates contributions from underlying common polymorphisms. We considered polymorphisms in the beta(1)-adrenergic receptor (beta(1)AR), a beta-blocker… Expand
Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.
- T. Greenwood, L. Lazzeroni, +24 authors D. Braff
- Biology, Medicine
- The American journal of psychiatry
- 1 September 2011
OBJECTIVE The authors used a custom array of 1,536 single-nucleotide polymorphisms (SNPs) to interrogate 94 functionally relevant candidate genes for schizophrenia and identify associations with 12… Expand
Physiological correlates of social avoidance behavior in children and adolescents with fragile x syndrome.
- S. Hall, A. Lightbody, L. Huffman, L. Lazzeroni, A. Reiss
- Psychology, Medicine
- Journal of the American Academy of Child and…
- 1 March 2009
OBJECTIVE To investigate whether eye-gaze avoidance, a striking phenotypic feature in fragile X syndrome (FXS), is associated with high levels of "hyperarousal" during social interactions with… Expand
A polymorphism within a conserved β1-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure
Heterogeneity of heart failure (HF) phenotypes indicates contributions from underlying common polymorphisms. We considered polymorphisms in the β1-adrenergic receptor (β1AR), a β-blocker target, as… Expand
ABCB1 (MDR1) polymorphisms and antidepressant response in geriatric depression
- J. E. Sarginson, L. Lazzeroni, H. Ryan, B. Ershoff, A. Schatzberg, G. Murphy
- Pharmacogenetics and genomics
- 1 August 2010
Objective Variation in the ATP-binding cassette, subfamily B, member 1 transporter (ABCB1) (multidrug-resistance gene 1) gene has been investigated as a predictor of response to treatment with a… Expand
A High-Resolution Radiation Hybrid Map of the Human Genome Draft Sequence
We have constructed a physical map of the human genome by using a panel of 90 whole-genome radiation hybrids (the TNG panel) in conjunction with 40,322 sequence-tagged sites (STSs) derived from… Expand
HPA Axis in Major Depression: Cortisol, Clinical Symptomatology, and Genetic Variation Predict Cognition
The hypothalamic–pituitary–adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity… Expand