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Selectivity of the antimetastatic and cytotoxic effects of 1-p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (+/-)-1,2-di(3,5-dioxopiperazin-1-yl)propane, and cyclophosphamide in mice bearing…
The effects of two selective antimetastatic agents, 1-p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (DM-COOK), and (+/-)-1,2-di(3,5-dioxopiperazin-1-yl)propane, have been examined in… Expand
Mechanism of the antimetastatic action of dimethyltriazenes.
Antimetastatic action and hematological toxicity of p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt and 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide used as prophylactic adjuvants to…
DM-COOK appears to exert selective antimetastatic effects, unrelated to cytotoxicity for tumor cells, against B16 melanoma in addition to those reported for Lewis lung carcinoma and M5 ovarian reticular cell sarcoma; its therapeutic usefulness is evidenced in adjuvant surgical experiments. Expand
Selective Antimetastatic Triazenes: A Quantitative Approach
Quantitative structure-activity relationships have been formulated examining a series of para substituted phenyldimethyl-triazenes for their differential effects on the subcutaneous growth of Lewis… Expand
Mechanism of the antileukemic effects of 1-p-carboxamidophenyl-3,3-dimethyltriazene and its in vitro metabolites.
- G. Sava, T. Giraldi, L. Lassiani, C. Nisi, P. Farmer
- Chemistry, Medicine
- Biochemical pharmacology
- 15 November 1982
The increase in survival time of mice bearing TLX5 lymphoma causing by the dimethyltriazenes used appears to be caused by the drugs without being subjected to metabolic activation, with a mechanism different from cytotoxicity for tumor cells. Expand
Anthranoyl-anthranilic acid : a template for the development of a new class of cholecystokinin receptor ligands
Metabolism and mechanism of the antileukemic action of isomeric aryldimethyltriazenes.
- G. Sava, T. Giraldi, L. Lassiani, C. Nisi
- Chemistry, Medicine
- Cancer treatment reports
- 1 September 1982
The data indicate that the increased survival time of the tumor-bearing mice treated with the para isomer should not be ascribed to cytotoxic effects of the drug and might be attributed to inhibition of tumor cell dissemination in various organs of the host, as already observed for solid metastasizing tumors in mice. Expand
C-terminal anthranoyl-anthranilic acid derivatives and their evaluation on CCK receptors.
A series of C-terminal anthranoyl-anthranilic acid derivatives arising from a strict bond disconnection approach of asperlicin were synthesized and examined for their CCK receptor affinities, confirming that the anthranilic Acid dimer represents a useful template for the development of selective CCK-A receptor ligands. Expand
Synthesis of new anthranilic acid dimer derivatives and their evaluation on CCK receptors.
A new series of anthranilic acid dimer derivatives, characterized by the presence of the tryptophan residue in the C-terminus of the dimer, is described, which exhibited an improved affinity for the CCK-A receptor in comparison to that of either, the N-unsubstituted derivative and asperlicin. Expand
Quinazolinone derivatives: synthesis and binding evaluation on cholecystokinin receptors.
The obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands. Expand