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Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
The gradual deterioration of cognitive functions in Alzheimer’s disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate that toxicExpand
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Amyloid-ß-directed immunotherapy for Alzheimer's disease
Current treatment options for Alzheimer's disease (AD) are limited to medications that reduce dementia symptoms. Given the rapidly ageing populations in most areas of the world, new therapeuticExpand
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Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders
Dysfunctions in dopaminergic transmission in the brain may occur in several mental disorders. Among the five dopamine receptor genes cloned, the dopamine D3 receptor is expressed almost exclusivelyExpand
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Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene inExpand
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Neurobiology: Presenilin-1 mutations in Alzheimer's disease
Mutations in the gene encoding the protein presenilin-1 are the most common cause of familial Alzheimer's disease and they often produce a different disease course from sporadic Alzheimer's andExpand
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Characterization of stable complexes involving apolipoprotein E and the amyloid β peptide in Alzheimer's disease brain
Genetic evidence suggests a role for apolipoprotein E (apoE) in Alzheimer's disease (AD) amyloidogenesis. Here, amyloid-associated apoE from 32 AD patients was purified and characterized. We foundExpand
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Increased cerebrospinal fluid tau in patients with Alzheimer's disease
One of the pathological features in Alzheimer's disease (AD) is neurofibrillary tangles in the brain. The main constituent of tangles is the microtubuli-associated protein tau in aExpand
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Consensus Paper of the WFSBP Task Force on Biological Markers of Dementia: The role of CSF and blood analysis in the early and differential diagnosis of dementia
Aging of population, and increasing life expectancy result in an increasing number of patients with dementia. This symptom can be a part of a completely curable disease of the central nervous systemExpand
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Physiochemical characterization of the Alzheimer's disease‐related peptides Aβ1–42Arctic and Aβ1–42wt
The amyloid β peptide (Aβ) is crucial for the pathogenesis of Alzheimer's disease. Aggregation of monomeric Aβ into insoluble amyloid fibrils proceeds through several soluble Aβ intermediates,Expand
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Docosahexaenoic acid stabilizes soluble amyloid‐β protofibrils and sustains amyloid‐β‐induced neurotoxicity in vitro
Enrichment of diet and culture media with the polyunsaturated fatty acid docosahexaenoic acid has been found to reduce the amyloid burden in mice and lower amyloid‐β (Aβ) levels in both mice andExpand
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