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Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
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Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex
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The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
TLDR
Two coupled cAMP-dependent feedback loops are coordinated within the context of the mAKAP complex, suggesting that local control of cAMP signalling by AKAP proteins is more intricate than previously appreciated.
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Association of protein kinase A and protein phosphatase 2B with a common anchoring protein.
TLDR
Results suggest that both PKA and CaN are targeted to subcellular sites by association with a common anchor protein and thereby regulate the phosphorylation state of key neuronal substrates.
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Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex.
TLDR
Yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity and targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation.
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AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
TLDR
It is shown here that rat KCNQ2 can bind directly to the multivalent A-kinase-anchoring protein AKAP150, and data indicate thatAKAP150-bound PKC participates in receptor-induced inhibition of the M-current.
View on Nature
Proteomic, Functional, and Domain-Based Analysis of In Vivo 14-3-3 Binding Proteins Involved in Cytoskeletal Regulation and Cellular Organization
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Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein
TLDR
Deletion analysis and binding studies demonstrate that a third enzyme, protein kinase C (PKC), binds AKAP79 at a site distinct from those bound by PKA or CaN, andAKAP79 appears to function as a scaffold protein for three multifunctional enzymes.
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Regulation of GluR1 by the A-Kinase Anchoring Protein 79 (AKAP79) Signaling Complex Shares Properties with Long-Term Depression
TLDR
It is demonstrated that AKAP79 not only promotes basal phosphorylation of Ser845 but also confers a calcium- and PP2B-mediated downregulation to GluR1 receptor currents, suggesting that the integration of intracellular signals relevant for LTD may be transduced to GLUR1 by theAKAP79 signaling complex.
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Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein
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