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The human keratins: biology and pathology
TLDR
Since keratins also exhibit characteristic expression patterns in human tumors, several of them have great importance in immunohistochemical tumor diagnosis of carcinomas, in particular of unclear metastases and in precise classification and subtyping. Expand
New consensus nomenclature for mammalian keratins
TLDR
This revised nomenclature accommodates functional genes and pseudogenes, and although designed specifically for the full complement of human keratins, it offers the flexibility needed to incorporate additional keratin proteins from other mammalian species. Expand
Keratins of the human hair follicle.
TLDR
The genomic organization of the human hair keratin gene family and the complex expression characteristics of hair keratins in the hair-forming compartment are described and the role and fate ofhair keratin in the diseased hair follicle is described. Expand
A Complex of EpCAM, Claudin-7, CD44 Variant Isoforms, and Tetraspanins Promotes Colorectal Cancer Progression
TLDR
expression of EpCAM, claudin-7, CO-029, and CD44v6 expression was up-regulated in colon cancer and liver metastasis and coexpression and complex formation of the molecules was correlated with clinical variables and apoptosis resistance. Expand
Human hair keratin-associated proteins (KAPs).
TLDR
This report delves into further aspects, such as polymorphic variations in human KAP genes, the role that KAP proteins might play in hereditary hair diseases, as well as their modulation in several different transgenic mouse models displaying hair abnormalities. Expand
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
TLDR
Using conditional gene targeting in mice, it is shown that the small GTPase Cdc42 is crucial for differentiation of skin progenitor cells into HF lineage and that it regulates the turnover of beta-catenin. Expand
The Catalog of Human Hair Keratins
TLDR
In situ hybridization and immunohistochemical expression studies on scalp follicles show that two hair keratins define the early stage of hair differentiation, i.e. hHa5 expression in hair matrix and hHa4/hHa2 coexpression in the early hair cuticle cells. Expand
A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle.
TLDR
Evidence is provided that, together with Henle cells, Flügelzellen ensure the maintenance of a continuous desmosomal anchorage of the companion layer along the entire inner root sheath unit provides an optimal molding and guidance of the growing hair shaft. Expand
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis
TLDR
It is concluded that ILK plays important roles for epidermis and hair follicle morphogenesis by modulating integrin-mediated adhesion, actin reorganization, and plasma membrane dynamics in keratinocytes. Expand
Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom.
TLDR
An unexpected diversity of TJ-related structures is found of which only those showing colocalization with the most restricted transmembrane TJ marker protein, occludin, are presented here. Expand
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