L. Lang

Publications132
h-index33
Citations3,565
Highly Influential Citations142
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Development of a Controlled Vocabulary and Software Application to Analyze Fruit Shape Variation in Tomato and Other Plant Species1[W]
The domestication and improvement of fruit-bearing crops resulted in a large diversity of fruit form. To facilitate consistent terminology pertaining to shape, a controlled vocabulary focusing… Expand
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Phase I/II safety and antitumor activity of nivolumab in patients with advanced hepatocellular carcinoma (HCC): CA209-040.
LBA101 Background: Overexpression of PD-L1 in HCC has a poor prognosis. Safety and preliminary antitumor efficacy of nivolumab, a fully human IgG4 monoclonal antibody PD-1 inhibitor, was evaluated in… Expand
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Generalized multiprotocol label switching: an overview of signaling enhancements and recovery techniques
TLDR
We present enhancements to two commonly used IP signaling protocols, RSVP and LDP, to support GMPLS, and describe the applications of suggested labels. Expand
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5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correction.
UNLABELLED Preclinical studies suggest that serotonin 1A receptors (5-HT 1A) play a role in temporal lobe epilepsy (TLE). Previous PET studies reported decreased 5-HT 1A binding ipsilateral to… Expand
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Brain Uptake of the Acid Metabolites of F-18—Labeled WAY 100635 Analogs
The 5-HT1A ligands [F]FPWAY and [18F]FCWAY are metabolized in vivo to [18F]fluorobenzoic acid (FB) and [18F]fluorocyclohexanecarboxylic acid (FC), respectively. To quantify the penetration of these… Expand
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Bayesian estimation via sequential Monte Carlo sampling - Constrained dynamic systems
TLDR
This paper describes a practical approach that overcomes these shortcomings via a novel extension of sequential Monte Carlo (SMC) sampling or particle filtering. Expand
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Immuno-PET of the Hepatocyte Growth Factor Receptor Met Using the 1-Armed Antibody Onartuzumab
The overexpression and overactivation of hepatocyte growth factor receptor (Met) in various cancers has been linked to increased proliferation, progression to metastatic disease, and drug resistance.… Expand
  • 36
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Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice.
[(18)F]FPPRGD2, an F-18 labeled dimeric cyclic RGDyK peptide, has favorable properties for PET imaging of angiogenesis by targeting the α(v)β(3) integrin receptor. This radiotracer has been approved… Expand
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PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2
  • H. Gao, L. Lang, +6 authors X. Chen
  • Medicine
  • European Journal of Nuclear Medicine and…
  • 25 January 2012
PurposeThe αvβ3 integrin represents a potential target for noninvasive imaging of angiogenesis. The purpose of this study was to evaluate a novel one-step labeled integrin αvβ3-targeting positron… Expand
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Development of fluorine-18-labeled 5-HT1A antagonists.
We have synthesized five fluorinated derivatives of WAY 100635, N-{2-[4-(2-methoxyphenyl)piperazino]ethyl}-N-(2-pyridyl)cyclohe xaneca rboxamide (4a), using various acids in place of the… Expand
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