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Effect of anionic surfactant molecular structure on bovine serum albumin (BSA) fluorescence
Abstract The interactions of BSA with different anionic surfactants, such as sodium alkyl sulfate (CnSO4Na, n = 8, 10 and 12), sodium alkyl sulfonate (CnSO3Na, n = 8, 10 and 12) and sodium alkyl
[Controlling arachidonic acid metabolic network: from single- to multi-target inhibitors of key enzymes].
  • Y. Liu, Zheng Chen, +6 authors L. Lai
  • Biology, Medicine
    Yao xue xue bao = Acta pharmaceutica Sinica
  • 1 March 2009
The goal of this review is mainly focused on the key enzymes in arachidonic acid metabolic network, such as phospholipase A2, cyclooxygenases, 5-lipoxygenase and eukotriene A4 hydrolase, which are used as key targets for the development of anti-inflammatory drugs.
Synthesis, fungicidal activity, and 3D-QSAR of pyridazinone-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles.
The 3D-QSAR modes gave good correlation between the variations on percent inhibition and the steric-electrostatic properties, and confirmed that the 1,3,4-oxadiazole ring is a bioisosteric analogue of the 2,2-arylamino-1,3-4-thiadiazoles ring.
Interaction between bovine serum albumin and equimolarly mixed cationic-anionic surfactants decyltriethylammonium bromide-sodium decyl sulfonate.
It was shown that the single ionic surfactant C10SO3 or C10NE has obvious interaction with BSA, however, the equimolarly mixed cationic-anionic surfactants C10 NE-C10SO 3 showed very weak interactions with B SA.
An isothermal titration calorimetric method to determine the kinetic parameters of enzyme catalytic reaction by employing the product inhibition as probe.
An isothermal titration calorimetric method was developed to measure the kinetic parameters of ribonuclease A catalytic hydrolysis of cytidine 2',3'-cyclic monophosphate and can be applied in other enzyme catalytic systems with inhibitive products.
Surfactant-induced refolding of lysozyme.
The surfactant-lysozyme interaction was investigated by circular dichroism, fluorescence, UV, dynamic light scattering, surface tension, turbidity measurements and lysozyme activity assay. A new way
3D-QSAR studies on tripeptide aldehyde inhibitors of proteasome using CoMFA and CoMSIA methods.
The CoMFA and CoMSIA field contour maps agree well with the structural characteristics of the binding pocket of beta5 subunit of 20S proteasome, which suggests that the 3D-QSAR models built in this paper can be used to guide the development of novel inhibitors of 20s proteasomes.
Organic cosolvents and hen egg white lysozyme folding.
It was found that trifluoroethanol (TFE) can change the folding pathway significantly and the overshot phenomenon generally observed in lysozyme folding at 222 nm disappears, hypothesized to be due to the similar influence of organic cosolvent on the transition state of heat denaturation and refolding.
Protein-surfactant interaction: differences between fluorinated and hydrogenated surfactants.
It was found that fluorinated surfactants exhibited stronger interactions with proteins than hydrogenated ones, which, however, depended on the structures of both proteins and surfactant molecules.
Interactions of β-lactoglobulin with sodium decylsulfonate, decyltriethylammonium bromide, and their mixtures
Abstract The interactions of β -lactoglobulin (BLG) with anionic surfactant sodium decylsulfonate (C 10 SO 3 ), cationic surfactant decyltriethylammonium bromide (C 10 NE), and the mixtures of