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Lingzhiols, unprecedented rotary door-shaped meroterpenoids as potent and selective inhibitors of p-Smad3 from Ganoderma lucidum.
(+)-Lingzhiol and (-)-lingzhiol, a pair of rotary door-shaped meroterpenoidal enantiomers, were isolated from Ganoderma lucidum. Their structures were identified by spectroscopic methods and X-ray… Expand
Smac/DIABLO and cytochrome c are released from mitochondria through a similar mechanism during UV-induced apoptosis
During apoptosis, a key event is the release of Smac/DIABLO (an inhibitor of XIAP) and cytochrome c (Cyt-c, an activator of caspase-9) from mitochondria to cytosol. It was not clear, however, whether… Expand
In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.
The phosphatidylinositol 3-kinase/AKT signaling pathway plays a critical role in activating survival and antiapoptotic pathways within cancer cells. Several studies have shown that this pathway is… Expand
Development of sulfonamide AKT PH domain inhibitors.
- Ali M Ahad, Song Zuohe, +6 authors E. Mash
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 March 2011
Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin… Expand
Involvement of bone marrow stem cells in periodontal wound healing.
OBJECTS To test the hypothesis whether bone marrow stem cells (BMSCs) could migrate into the periodontium as the precursor available for the repair of tissue injury. METHODS A chimeric mouse model… Expand
A novel four-wing non-equilibrium chaotic system and its circuit implementation
In this paper, we construct a novel, 4D smooth autonomous system. Compared to the existing chaotic systems, the most attractive point is that this system does not display any equilibria, but can… Expand
The Exploration of Regional Characteristics of Architecture Based on Historical Context Inheritance and City Characteristics Shaping
This paper discusses the relationship of the regional characteristics of architecture based on historical context and the characteristics of city, summarizes the response to the losing… Expand
Formation and Magic Number Characteristic of Clusters during Rapid Solidification of Mg2Ca
A molecular dynamics simulation study has been performed for a system consisting of 15,000 atoms to investigate the formation and magic number characteristics of various clusters formed during the… Expand
Effects of bFGF and Collagen on the Construction of Tissue Engineering Cartilage In Vitro in the 3-D Culture System
Objective: To investigate effects of bFGF and collagen on tissue-engineered cartilage in pellet culture. Methods: Rabbit rib growth-plate chondrocytes were incubated in pellet culture. bFGF and… Expand
Research on Dynamics Simulation of Buffering Process of Docking Mechanism
On-orbit service technology can extend the working life of the spacecraft, and improve the ability to perform various tasks. Docking mechanism is the key equipment of the space docking. The cushion… Expand