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Chromosome 18 transcriptome profiling and targeted proteome mapping in depleted plasma, liver tissue and HepG2 cells.
The final goal of the Russian part of the Chromosome-centric Human Proteome Project (C-HPP) was established as the analysis of the chromosome 18 (Chr 18) protein complement in plasma, liver tissueExpand
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Chromosome 18 transcriptoproteome of liver tissue and HepG2 cells and targeted proteome mapping in depleted plasma: update 2013.
We report the results obtained in 2012-2013 by the Russian Consortium for the Chromosome-centric Human Proteome Project (C-HPP). The main scope of this work was the transcriptome profiling of genesExpand
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Application of selected reaction monitoring and parallel reaction monitoring for investigation of HL-60 cell line differentiation
Targeted mass spectrometry represents a powerful tool for investigation of biological processes. The convenient approach of selected reaction monitoring using stable isotope-labeled peptide standardExpand
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RNA-Seq gene expression profiling of HepG2 cells: the influence of experimental factors and comparison with liver tissue
BackgroundHuman hepatoma HepG2 cells are used as an in vitro model of the human liver. High-throughput transcriptomic sequencing is an advanced approach for assessing the functional state of a tissueExpand
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The "missing" proteome: undetected proteins, not-translated transcripts, and untranscribed genes.
The Chromosome-centric Human Proteome Project aims at characterizing at tissue, cell, and subcellular levels the expression of proteins encoded in each chromosome. The proteomic profiling of aExpand
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Zinc-Mediated Binding of Nucleic Acids to Amyloid-β Aggregates: Role of Histidine Residues.
Amyloid-β peptide (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis. Besides extracellular Aβ, intraneuronal Aβ (iAβ) has been suggested to contribute to AD onset and development.Expand
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Mesenchymal Stem Cells in the Adult Human Liver: Hype or Hope?
Chronic liver diseases constitute a significant economic, social, and biomedical burden. Among commonly adopted approaches, only organ transplantation can radically help patients with end-stage liverExpand
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[Comparative transcriptomic and proteomic analysis of the fetal and adult human liver].
The transcriptome and proteome comparative analysis of the fetal liver (9.5-10.5 weeks of gestation) and normal adult liver was developed in the present investigation. We used 44k microarrays ofExpand
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Detection of marker miRNAs in plasma using SOI-NW biosensor
Abstract This work demonstrates the possibility of detection of DNA-oligonucleotide (oDNA) and microRNAs (miRNAs) extracted from blood plasma and associated with breast cancer (BC) in a bufferExpand
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Harnessing the Potential of Killers and Altruists within the Microbial Community: A Possible Alternative to Antibiotic Therapy?
In the context of a post-antibiotic era, the phenomenon of microbial allolysis, which is defined as the partial killing of bacterial population induced by other cells of the same species, may take onExpand
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