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Inhibitors of protein phosphatase‐2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau
- I. Tsujio, T. Zaidi, J. Xu, L. Kotula, I. Grundke-Iqbal, K. Iqbal
- Medicine, Biology
- FEBS letters
- 17 January 2005
Protein phosphatase (PP)‐2A, which regulates the phosphorylation of tau, is regulated by two endogenous inhibitor proteins, I 1 PP 2 A and I 2 PP 2 A , in mammalian tissues. Here, we report the… Expand
Structural analysis of the αN-terminal region of erythroid and nonerythroid spectrins by small-angle X-ray scattering
: We used SpalphaI-1-156 peptide, a well-characterized model peptide of the alphaN-terminal region of erythrocyte spectrin, and SpalphaII-1-149, an alphaII brain spectrin model peptide similar in… Expand
Essential role for Abi1 in embryonic survival and WAVE2 complex integrity
- P. Dubielecka, Kathrin I. Ladwein, +7 authors L. Kotula
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 11 April 2011
Abl interactor 1 (Abi1) plays a critical function in actin cytoskeleton dynamics through participation in the WAVE2 complex. To gain a better understanding of the specific role of Abi1, we generated… Expand
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1.
Here we report c-Abl kinase inhibition mediated by a phosphotyrosine located in trans in the c-Abl substrate, Abi1. The mechanism, which is pertinent to the nonmyristoylated c-Abl kinase, involves… Expand
Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.
- S. M. Nawshad Hossain, Patrycja M Dubielecka, Aleksander F. Sikorski, Raymond B. Birge, Leszek Kotula
- Biology, Medicine
- Genes & cancer
- 7 October 2012
The nonreceptor tyrosine kinases Abl and Arg are among the most well-characterized tyrosine kinases in the human genome. The activation of Abl by N-terminal fusions with Bcr (Bcr-Abl) or Gag (v-Abl)… Expand
Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI‐3 kinase in regulation of macropinocytosis in LNCaP cells
MINT‐7908027: Abi1 (uniprotkb:Q8IZP0) binds (MI:0407) to Lck (uniprotkb:P06239) by array technology (MI:0008)
Altered binding of mutated presenilin with cytoskeleton‐interacting proteins 1
The majority of familial Alzheimer's disease (AD) cases are linked to mutations on presenilin 1 and 2 genes (PS1 and PS2). The normal function of the proteins and the mechanisms underlying… Expand
Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells.
Macropinocytosis is an endocytic process that occurs through non-clathrin coated vesicles larger than 0.2 microm in diameter. Although macropinocytic vesicles are readily visualized in cultured cells… Expand
Loss of expression of human spectrin src homology domain binding protein 1 is associated with 10p loss in human prostatic adenocarcinoma.
The gene encoding human spectrin Src homology domain binding protein 1, or Hssh3bp1, which is a marker of macropinocytic vesicles and a potential regulator of macropinocytosis, co-localizes to a YAC… Expand
Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer
Tunneling nanotubes (TNTs) are actin-based membranous structures bridging distant cells for intercellular communication. We define roles for TNTs in stress adaptation and treatment resistance in… Expand