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Low expression allele alpha LELY of red cell spectrin is associated with mutations in exon 40 (alpha V/41 polymorphism) and intron 45 and with partial skipping of exon 46.
It is hypothesized that the lack of exon 46 would hamper the nucleation process and eventually account for the low expression feature of the alpha V/41 polymorphism, and the present doubly mutated allele was renamed allele alpha LELY (low expression, Lyon).
Two distinct mechanisms for regulation of nonmuscle myosin assembly via the heavy chain: phosphorylation for MIIB and mts 1 binding for MIIA.
The results suggest strongly that assembly of MIIA and MIIB is regulated by distinct mechanisms via tail-end domains: phosphorylation of M IIB and mts 1 binding to MIIA.
Physical properties of a single-motif erythrocyte spectrin peptide: a highly stable independently folding unit.
Data show that this 13 kDa spectrin motif is a monomeric, highly stable, triple-helical, independently folding protein building block with physical characteristics that define many of the structural properties of the 526 k da spectrin heterodimer.
Essential role for Abi1 in embryonic survival and WAVE2 complex integrity
- P. Dubielecka, K. Ladwein, L. Kotula
- BiologyProceedings of the National Academy of Sciences
- 11 April 2011
It is suggested that the presence of Abi1 is critical for the integrity and stability of WAVE complex and that Abi2 levels are not sufficiently increased to compensate fully for the loss ofAbi1 in KO cells and to restore the integrityand function of theWAVE complex.
Inhibitors of protein phosphatase‐2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau
Identification of a Candidate Human Spectrin Src Homology 3 Domain-binding Protein Suggests a General Mechanism of Association of Tyrosine Kinases with the Spectrin-based Membrane Skeleton*
- D. Ziemnicka-Kotula, Jiliu Xu, L. Kotula
- Biology, ChemistryThe Journal of Biological Chemistry
- 29 May 1998
Overexpression of the green fluorescent protein fusion of the SH3 domain-binding protein in NIH3T3 cells resulted in cytoplasmic punctate fluorescence characteristic of the reticulovesicular system.
Structural Analysis of the αN-Terminal Region of Erythroid and Nonerythroid Spectrins by Small-Angle X-ray Scattering†
It is suggested that this particular junction region in alpha-spectrin plays a major role in modulating its association affinity with beta-spectrins, and thus regulates spectrin tetramer levels.
Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.
- S. Hossain, P. Dubielecka, A. Sikorski, R. Birge, L. Kotula
- Biology, ChemistryGenes & cancer
- 7 October 2012
New insights into the structure of these kinases provide the rationale to envision that Crk and Abi1 fine-tune Abl regulation to control signaling to the cytoskeleton, and this review addresses the role of Abl and Arg in tumor progression with particular emphasis on the roles of Crk/Abi1 adapter proteins as distinct molecular switches for Abl transactivation.
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1.