L. Kolik

Publications90
h-index5
Citations117
Highly Influential Citations1
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Design and synthesis of cholecystokinin-4 dipeptide analogues with anxiolytic and anxiogenic activities
TLDR
The dipeptide Ph(CH2)5CO-Gly-L-Trp-NH2 with the activity in rats of 0.05–0.2 mg/kg after oral and intraperitoneal administration was chosen for further studies as a promising anxiolytic agent.
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Atria Depolarization in Rats with Alcoholic Cardiomyopathy
Chronotopography of atrial subepicardium depolarization has been studied in a rat model of alcoholic cardiomyopathy. Formation of independent sources of initial atrial activity has been detected in…
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Preclinical Pharmacokinetic and Pharmacodynamic Studies of Pharmaceutical Compositions of the Dipeptide Anxiolytic GB-115
TLDR
Four pharmaceutical compositions for oral use that contained the dipeptide anxiolytic GB-115 as the active ingredient underwent preclinical trials in male laboratory white rats and it was shown that compositions 2 and 4 had advantages according to the main pharmacokinetic characteristics reflecting the bioavailability ofGB-115.
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P.6.c.003 The BDNF mimetic GSB-106 produces long-term analgesia and significant reduction of opiate withdrawal signs: comparison with dipeptide anxiolytic GB-115 effects in rats
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Anxiolytic Properties of Trimetazidine in Experimental Models of Increased Anxiety
TLDR
In outbred male rats receiving 10% ethanol solution for 20 weeks, trimetazidine administered intraperitoneally in a dose of 20 mg/kg for 28 days abolished ethanol withdrawal-induced anxiogenesis developed against the background of 4-week alcohol deprivation.
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Pharmacogenetic Study of Anxiolytic Effects of New Cholecystokinin Receptor Antagonists in Animals with Different Levels of Emotionality
TLDR
These data confirm anxioselective effects of the test compounds and produce an anxiolytic effect on MR rats (but not on MNRA rats) in the elevated plus-maze and conflict tests.
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Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity
TLDR
It is established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5–48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.
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Comparative Assessment of the Effectiveness of Noncompetitive NMDA Receptor Antagonists Amantadine and Hemantane in Morphine Withdrawal Syndrome Model
TLDR
Comparison of aminoadamantane derivatives by behavioral and physiological parameters demonstrated the advantage of hemantane during morphine abstinence indicating the need of its study as a promising anti-addiction remedy.
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Efficacy of Peptide Anxiolytic Selank during Modeling of Withdrawal Syndrome in Rats with Stable Alcoholic Motivation
TLDR
It is suggested that selank is effective in eliminating of alcohol withdrawal symptoms in rats.
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Alcoholic Cardiomyopathy: Translation Model
TLDR
Fatty degeneration of the myocardium and decrease in electrical stability of cardiomyocytes reliably reproduce the clinical pattern of alcoholicCardiomyopathy in rats.
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