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Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissectionExpand
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Lymphoid priming in human bone marrow begins before expression of CD 10 with upregulation of L-selectin
Although much is known about the identity of progenitor stages in mouse lymphopoiesis, considerably less is understood about the critical stages of lymphoid commitment of human hematopoietic cells.Expand
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Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome
Dominant-negative variants of STAT3 do not account for all cases of autosomal dominant hyper-IgE syndrome (HIES). Béziat et al. report HIES patients with dominant-negative variations of IL6ST,Expand
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Lymphoid Priming in Human Bone Marrow Begins Prior to CD10 Expression with Up-Regulation of L-selectin
Expression of the cell-surface antigen CD10 has long been used to define the lymphoid commitment of human cells. Here we report a unique lymphoid-primed population in human bone marrow that wasExpand
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Human Lymphoid Development in the Absence of Common γ-Chain Receptor Signaling
Despite the power of model systems to reveal basic immunologic mechanisms, critical differences exist between species that necessitate the direct study of human cells. Illustrating this point is theExpand
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Treatment of Systemic Mastocytosis in an Infant with Midostaurin.
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Rapid thymic reconstitution following bone marrow transplantation in neonatal mice is VEGF-dependent.
Age-related differences in thymic function influence the rapidity of T cell reconstitution following hematopoietic stem cell transplantation (HSCT). In adults, thymic reconstitution is delayed untilExpand
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Human Lymphoid Development in the Absence of Common gamma-Chain Receptor Signaling
Public Summary: The entire immune system develops in the bone marrow from hematopoietic stem cells (HSC) through a set of carefully regulated stages. The earliest stages of differentiation from HSCExpand
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