L. Kohn

Publications29
h-index14
Citations1,057
Highly Influential Citations22
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Cytotoxic activity of (S)-goniothalamin and analogues against human cancer cells.
Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip.
Styryl lactones and their derivatives: biological activities, mechanisms of action and potential leads for drug design.
TLDR
The biological activities of styryl lactones focusing on cancer cells, the causal agent of Chagas' disease and the vectors for yellow fever and human lymphatic filariasis are discussed, as well as immunosuppressive and inflammatory processes.
(R)-Goniothalamin: total syntheses and cytotoxic activity against cancer cell lines.
Antiproliferative properties of polyketides isolated from Virola sebifera leaves
TLDR
An activity‐guided fractionation of Virola sebifera Aubl provided novel methylene chloride‐soluble fraction that showed selectivity against human OVCAR03 and NCI‐ADR cell lines, ranging from 2 to 4 µg/mL.
Synthesis and differential antiproliferative activity of Biginelli compounds against cancer cell lines: Monastrol, oxo-monastrol and oxygenated analogues.
Cytotoxicity of tamoxifen in normal and tumoral cell lines and its ability to induce cellular transformation in vitro
New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
Antiproliferative effect of Baylis-Hillman adducts and a new phthalide derivative on human tumor cell lines.
Antiproliferative activity of Luehea candicans Mart. et Zucc. (Tiliaceae)
TLDR
The crude methanolic extracts from the branches and leaves and their fractions were able to inhibit the growth of the K-562 and 786-0 cell lines in a dose-dependent manner, with GI50 values of 8.1 and 5.4 µg mL−1, respectively.
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