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Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems
TLDR
A functional and regulatory cross‐talk between three chromosomal PAIs, SPI‐1, SPI-2 and SPI‐5, has significant implications for the evolution and role of PAIs in bacterial pathogenesis.
Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia
TLDR
It is demonstrated that a subpopulation of Salmonella hyperreplicating in the cytosol of epithelial cells serves as a reservoir for dissemination and provides a mechanistic explanation for the mucosal inflammation that is triggered duringSalmonella infection of the gastrointestinal and biliary tracts.
Activation of Akt/Protein Kinase B in Epithelial Cells by theSalmonella typhimurium Effector SigD*
TLDR
It is found that Akt is activated by Salmonella enterica serovar Typhimurium in epithelial cells and SigD is the first bacterial effector to be identified as an activator of Akt.
The Salmonella effector protein PipB2 is a linker for kinesin-1
TLDR
The data indicate that the TTSS-2-mediated fine-tuning of kinesin-1 activity associated with the bacterial vacuole is crucial for the virulence of Salmonella.
Salmonella enterica serovar Typhimurium effector SigD/SopB is membrane‐associated and ubiquitinated inside host cells
TLDR
It is shown here that SigD is a membrane‐associated protein that is ubiquitinated inside host cells, the first direct evidence of a bacterial effector protein being ubiquitination.
Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.
TLDR
An epithelial cell-intrinsic noncanonical inflammasome plays a critical role in antimicrobial defense at the intestinal mucosal surface in caspase-11-deficient mice.
The Salmonella Effector Protein SopB Protects Epithelial Cells from Apoptosis by Sustained Activation of Akt*
TLDR
It is shown that SopB/SigD, an effector with phosphoinositide phosphatase activity, has anti-apoptotic activity in Salmonella-infected epithelial cells, providing new insights into the mechanisms of apoptosis and highlighting how bacterial effectors can intercept signaling pathways to manipulate host responses.
Salmonella typhimurium Virulence Genes Are Induced upon Bacterial Invasion into Phagocytic and Nonphagocytic Cells
TLDR
All but one of the genes identified in this study were virulence factors within pathogenicity islands, illustrating the requirement for specific gene expression inside mammalian cells and indicating the key role that virulence factor regulation plays in Salmonella pathogenesis.
The invasion‐associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells
TLDR
A previously unknown role for SPI‐1 in vacuole biogenesis and intracellular survival in non‐phagocytic cells is demonstrated.
Salmonella type III effectors PipB and PipB2 are targeted to detergent‐resistant microdomains on internal host cell membranes
TLDR
A new Salmonella effector is described, PipB2, which has sequence similarity to another type III effector, pipB, which is enriched in detergent‐resistant microdomains (DRMs) present on membranes of SCVs and Sifs.
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