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The contributions of UVA and UVB to connective tissue damage in hairless mice.
TLDR
Like UVB, the UVA waveband, especially that with a spectral distribution similar to solar UVA, caused elastic fiber damage, increased glycosaminoglycan levels, and produced hypertrophy of deep dermal tissues and substantial protection was afforded by a broad-spectrum sunscreen.
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Topical retinoic acid enhances the repair of ultraviolet damaged dermal connective tissue.
TLDR
In contrast to controls treated with vehicle, the reconstruction zone was significantly wider in RA-treated mice, and the enhanced repair was dose related.
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In vitro model for contact sensitization: I. Stimulatory capacities of human blood-derived dendritic cells and their phenotypical alterations in the presence of contact sensitizers.
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Photoaging. Manifestations, prevention, and treatment.
  • L. Kligman
  • Medicine
    Clinics in geriatric medicine
  • 1 February 1989
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The ultraviolet-irradiated hairless mouse: a model for photoaging.
  • L. Kligman
  • Biology, Medicine
    Journal of the American Academy of Dermatology
  • 1 September 1989
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BIOCHEMICAL CHANGES IN HAIRLESS MOUSE SKIN COLLAGEN AFTER CHRONIC EXPOSURE TO ULTRAVIOLET‐A RADIATION *
TLDR
It is suggested that chronic UV‐A radiation may increase cross‐linking of dermal collagen in Albino hairless mice by increasing the dose response at 4000 and 8000 J/cm2 as delivered by the UVASUN.
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AN ACTION SPECTRUM FOR ULTRAVIOLET INDUCED ELASTOSIS IN HAIRLESS MICE: QUANTIFICATION OF ELASTOSIS BY IMAGE ANALYSIS
TLDR
The erythema spectrum was the most predictive for elastosis except that the longer UVA wavelengths were less effective forElastosis than for ery thema, and solar simulating radiation (WG 320 filter) with its UVB component was theMost effective in inducing elastrosis.
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UVA-induced ultrastructural changes in hairless mouse skin: a comparison to UVB-induced damage.
  • P. Zheng, L. Kligman
  • Medicine, Biology
    The Journal of investigative dermatology
  • 1 February 1993
In this ultrastructural study, albino hairless mice were irradiated with long-wavelength ultraviolet (UVA) (340-400 nm) thrice weekly for 32 weeks for a cumulative dose of 8000 J/cm2. Biopsies were…
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The effect on rhino mouse skin of agents which influence keratinization and exfoliation.
TLDR
The skin of the rhino mouse, an allelic variant of the hariless mouse, contains deep dermal cysts and huge numbers of hornfilled utriculi which resemble comedones, a suitable model for assessing chemicals which affect epithelial differentiation (retinoids) or which promote loss of cohesion between horny cells (descaling agents).
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The hairless mouse model for photoaging.
  • L. Kligman
  • Biology
    Clinics in dermatology
  • 1 March 1996
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