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Identification of Antifungal H+-ATPase Inhibitors with Effect on Plasma Membrane Potential
- L. Kjellerup, S. Gordon, K. O. Cohrt, W. D. Brown, A. Fuglsang, A. L. Winther
- Chemistry, Medicine
- Antimicrobial Agents and Chemotherapy
- 24 April 2017
ABSTRACT The plasma membrane H+-ATPase (Pma1) is an essential fungal protein and a proposed target for new antifungal medications. The compounds in a small-molecule library containing ∼191,000… Expand
Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity
- Maike Bublitz, L. Kjellerup, +8 authors A. L. Winther
- Chemistry, Medicine
- PloS one
- 2 January 2018
We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship using… Expand
High-resolution screening combined with HPLC-HRMS-SPE-NMR for identification of fungal plasma membrane H(+)-ATPase inhibitors from plants.
- K. T. Kongstad, S. Wubshet, +4 authors D. Staerk
- Chemistry, Medicine
- Journal of agricultural and food chemistry
- 6 June 2014
Crude extracts of 33 plant species were assessed for fungal plasma membrane (PM) H(+)-ATPase inhibition. This led to identification of 18 extracts showing more than 95% inhibition at a concentration… Expand
Fungal plasma membrane H⁺-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv.
- K. T. Kongstad, S. Wubshet, L. Kjellerup, A. L. Winther, D. Staerk
- Chemistry, Medicine
- Fitoterapia
- 1 September 2015
In our ongoing efforts of finding natural fungicides to fight food and feed spoilage during production and storage, the antifungal potential of Ghanaian Uvaria chamae P. Beauv. was investigated, with… Expand
Cyclic AMP Pathway Activation and Extracellular Zinc Induce Rapid Intracellular Zinc Mobilization in Candida albicans
- L. Kjellerup, A. L. Winther, D. Wilson, A. Fuglsang
- Chemistry, Medicine
- Front. Microbiol.
- 21 March 2018
Zinc is an essential micronutrient, required for a range of zinc-dependent enzymes and transcription factors. In mammalian cells, zinc serves as a second messenger molecule. However, a role for zinc… Expand
Novel Zinc-Attenuating Compounds as Potent Broad-Spectrum Antifungal Agents with In Vitro and In Vivo Efficacy
- K. O. Cohrt, L. Marín, +4 authors A. L. Winther
- Chemistry, Medicine
- Antimicrobial Agents and Chemotherapy
- 12 February 2018
ABSTRACT An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for new broad-spectrum antifungals… Expand
Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives
- J. Clausen, L. Kjellerup, K. O. Cohrt, J. B. Hansen, W. Dalby-Brown, A. L. Winther
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 October 2017
Graphical abstract
FLOT - Förprojekt Lättviktskonstruktioner Offshore Topside
- Johan Edvardsson, L. Kjellerup, M. Amen, Kerstin Hindrum, T. Hertzberg
- Geology
- 2013
- 1
- PDF
National forvaltningsplan for laks
- P. Simonsen, L. Kjellerup, A. Koed, E. Nielsen
- 2004
Den ægte danske laks lever i Vestjylland. Godt nok er bestandene meget små, men biologerne mener, at bestandene kan reddes, hvis der sættes ind med en redningsplan nu. For 10-15 år siden mente man,… Expand
- 1
Structure of the (SR) Ca2+-ATPase bound to a Tetrahydrocarbazole and TNP-ATP
- Maike Bublitz, L. Kjellerup, +8 authors A. L. Winther
- Chemistry
- 10 January 2018