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Identification of Antifungal H+-ATPase Inhibitors with Effect on Plasma Membrane Potential
ABSTRACT The plasma membrane H+-ATPase (Pma1) is an essential fungal protein and a proposed target for new antifungal medications. The compounds in a small-molecule library containing ∼191,000Expand
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Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity
We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship usingExpand
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High-resolution screening combined with HPLC-HRMS-SPE-NMR for identification of fungal plasma membrane H(+)-ATPase inhibitors from plants.
Crude extracts of 33 plant species were assessed for fungal plasma membrane (PM) H(+)-ATPase inhibition. This led to identification of 18 extracts showing more than 95% inhibition at a concentrationExpand
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Fungal plasma membrane H⁺-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv.
In our ongoing efforts of finding natural fungicides to fight food and feed spoilage during production and storage, the antifungal potential of Ghanaian Uvaria chamae P. Beauv. was investigated, withExpand
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Cyclic AMP Pathway Activation and Extracellular Zinc Induce Rapid Intracellular Zinc Mobilization in Candida albicans
Zinc is an essential micronutrient, required for a range of zinc-dependent enzymes and transcription factors. In mammalian cells, zinc serves as a second messenger molecule. However, a role for zincExpand
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Novel Zinc-Attenuating Compounds as Potent Broad-Spectrum Antifungal Agents with In Vitro and In Vivo Efficacy
ABSTRACT An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for new broad-spectrum antifungalsExpand
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Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives
Graphical abstract
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National forvaltningsplan for laks
Den ægte danske laks lever i Vestjylland. Godt nok er bestandene meget små, men biologerne mener, at bestandene kan reddes, hvis der sættes ind med en redningsplan nu. For 10-15 år siden mente man,Expand
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