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Identification of Antifungal H+-ATPase Inhibitors with Effect on Plasma Membrane Potential
- L. Kjellerup, Sandra Gordon, K. O. Cohrt, W. D. Brown, A. Fuglsang, A. L. Winther
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 24 April 2017
The present inhibitors could serve as a starting point for the development of new antifungal agents with a novel mode of action, and reveal a dual mechanism for the previously identified cationic peptide BM2, revealing fungal membrane disruption, in addition to Pma1 inhibition.
Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity
It is found that tetrahydrocarbazoles inhibit adenosine triphosphate (ATP) hydrolysis of thefungal H+-ATPase, depolarize the fungal plasma membrane and exhibit broad-spectrum antifungal activity.
High-resolution screening combined with HPLC-HRMS-SPE-NMR for identification of fungal plasma membrane H(+)-ATPase inhibitors from plants.
- K. T. Kongstad, S. Wubshet, D. Staerk
- Chemistry, BiologyJournal of agricultural and food chemistry
- 6 June 2014
Chebulagic acid and tellimagrandin II are both potent inhibitors of the PM H(+)-ATPase with inhibitory effect on the growth of S. cerevisiae and Candida albicans.
Fungal plasma membrane H⁺-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv.
Novel Zinc-Attenuating Compounds as Potent Broad-Spectrum Antifungal Agents with In Vitro and In Vivo Efficacy
Two novel zinc-attenuating compounds are identified and characterization, ZAC307 and ZAC989, which exhibit broad-spectrum in vitro antifungal activity and in vivo efficacy in a fungal kidney burden candidiasis model and are determined to be fungistatic, with a low propensity for resistance development.
Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives
Cyclic AMP Pathway Activation and Extracellular Zinc Induce Rapid Intracellular Zinc Mobilization in Candida albicans
It is shown that activation of the cyclic AMP/PKA pathway triggers intracellular zinc mobilization in a fungus, the first described link between cyclicAMP signaling and zinc homeostasis in a human fungal pathogen.
Structure of the (SR) Ca2+-ATPase bound to a Tetrahydrocarbazole and TNP-ATP