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Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.
The mammalian target of rapamycin (mTOR) pathway integrates insulin and nutrient signaling in numerous cell types. Recent studies also suggest that this pathway negatively modulates insulin signalingExpand
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Granulocyte-macrophage colony-stimulating factor enhances 5-lipoxygenase levels in human polymorphonuclear leukocytes.
Stimulation of human polymorphonuclear leukocytes (PMNL) with granulocyte-macrophage CSF (GM-CSF) results in the enhanced expression of several genes, including some coding for cytokines and enzymes.Expand
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Hepatitis C virus NS2 protein inhibits gene expression from different cellular and viral promoters in hepatic and nonhepatic cell lines.
The mechanisms leading to viral persistence and hepatocarcinogenesis in hepatitis C virus (HCV) infection are not fully understood. Recently, evidence has been accumulated that HCV viral proteinsExpand
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Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development.
BACKGROUND & AIMS The insulin growth factor signal transduction pathway is an important regulator of adult hepatocyte proliferation. The purpose of this study was to determine the roles of theExpand
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Correlation of alpha-fetoprotein expression in normal hepatocytes during development with tyrosine phosphorylation and insulin receptor expression.
The molecular mechanism of hepatic cell growth and differentiation is ill defined. In the present study, we examined the putative role of tyrosine phosphorylation in normal rat liver development andExpand
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Phenotypic variability of cultured rat hepatoma cell population in respect to alpha‐fetoprotein synthesis
McA‐RH 7777 hepatoma cells were cloned on 2 occasions a week apart (test cloning). Alpha‐fetoprotein (AFP) phenotypes of primary and secondary clones from 55 primary clones were estimated. HighExpand
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Alpha-fetoprotein (AFP) expression in clones of McA-RH 7777 rat hepatoma: correlation with the occurrence of homogeneously staining regions on chromosome 14.
alpha-Fetoprotein (AFP) is a well-established cell differentiation and tumor marker. We showed previously that McA-RH 7777 hepatoma cells are heterogeneous in terms of their AFP cellular expression.Expand
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Detection and isolation of antibody-forming clones by local cytolysis in gel
To select clones of hybridomas producing monoclonal antibodies (MCA) of required specificity, many different methods have been suggested. However, all, as a rule, are based on testing culture fluidExpand
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Intraclonal variation in hepatoma cell line McA-RH 7777 revealed by analytical cloning
[Detection and isolation of antibody-forming clones by means of local cytolysis in gel].
A method is suggested combining the screening and cloning of hybridomas producing cytotoxic antibodies. The method is based on the Erne local hemolysis principles. The cells from the preformedExpand