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Endothelin A receptor is necessary for O2 constriction but not closure of ductus arteriosus.
In vitro and in vivo techniques were developed with genetically modified mice to determine whether endothelin-1 (ET-1) functions as an O2 mediator in closure of the ductus arteriosus (DA) at birth.Expand
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Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats.
Type A cholecystokinin receptor (CCKAR) antagonists differing in blood-brain barrier permeability were used to test the hypothesis that duodenal delivery of protein, carbohydrate, and fat producesExpand
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In vivo protective effects of tetrapeptide AcSDKP, with or without granulocyte colony-stimulation factor, on murine progenitor cells after sublethal irradiation.
Acetyl-N-Ser-Asp-Lys-Pro (AcSDKP) demonstrated hemato-protective activity in mice after sublethal irradiation (7 GY). Bone marrow interleukin-3 (IL-3)-responsive colony-forming cells (CFC and highExpand
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Studies on optimal dose and administration schedule of a hematopoietic stimulatory beta-(1,4)-linked mannan.
Several complex carbohydrates have been found to significantly stimulate hematopoiesis. CARN 750, a polydispersed beta-(1,4)-linked acetylated mannan isolated from the Aloe vera plant, has been shownExpand
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Interleukin-12 enhances peripheral hematopoiesis in vivo.
Interleukin 12(IL-12) is a cytokine that supports the proliferation and activation of cytotoxic T lymphocytes and natural killer (NK) cells. Recent evidence has suggested that IL-12 also hasExpand
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In vivo haemoprotective activity of tetrapeptide AcSDKP combined with granulocyte‐colony stimulating factor following sublethal irradiation
We report that acetyl‐n‐Ser‐Asp‐Lys‐Pro (AcSDKP), which removes progenitor cells from cell cycle, in combination with granulocyte‐colony stimulating factor (G‐CSF) can significantly improveExpand
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Ex vivo purging by adenoviral p53 gene therapy does not affect NOD-SCID repopulating activity of human CD34+ cells
Co-incubation of a replication-deficient, recombinant adenovirus carrying the wild-type p53 gene (rAd-p53) and hematopoietic stem cell (HSC) products from patients with breast cancer canExpand
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Hematopoietic augmentation by a β-(1,4)-linked mannan
Abstract CARN 750 (injectable acemannan) is a polydispersed β-(1,4)-linked acetylated mannan isolated from the Aloe barbadensis plant. It has multiple therapeutic properties including activity inExpand
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Effects of peripheral CCK receptor blockade on gastric emptying in rats.
Type A CCK receptor (CCKAR) antagonists differing in blood-brain barrier permeability [devazepide penetrates; the dicyclohexylammonium salt of Nalpha-3-quinolinoyl-d-Glu-N,N-dipentylamide (A-70104)Expand
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Adenovirus p53 Purging for Human Breast Cancer Stem Cell Products
Tumor cell (TC) contamination of stem cell products can contribute to relapse after high dose chemotherapy and stem cell rescue. A new purging technology using replication-deficient recombinantExpand
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