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Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
It is shown that mutations in ADAR1 cause the autoimmune disorder Aicardi-Goutières syndrome (AGS), and it is speculated that ADar1 may limit the cytoplasmic accumulation of the dsRNA generated from genomic repetitive elements.
The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA
Dynamic landscape and regulation of RNA editing in mammals
This work curated an extensive set of ADAR1 and ADAR2 targets and showed that many editing sites display distinct tissue-specific regulation by the ADAR enzymes in vivo, suggesting stronger cis-directed regulation of RNA editing for most sites, although the small set of conserved coding sites is under stronger trans-regulation.
Identifying RNA editing sites using RNA sequencing data alone
We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA…
Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein.
These and related findings support the idea that GAL4 activates transcription by touching other DNA-bound proteins.
A-to-I Pre-mRNA Editing in Drosophila Is Primarily Involved in Adult Nervous System Function and Integrity
Dynamic association of RNA-editing enzymes with the nucleolus
- J. Desterro, L. Keegan, M. Lafarga, M. Berciano, M. O’Connell, M. Carmo-Fonseca
- BiologyJournal of Cell Science
- 1 May 2003
ADAR1 and ADAR2 are editing enzymes that deaminate adenosine to inosine in long double stranded RNA duplexes and specific pre-mRNA transcripts and might be recruited onto specific editing substrates present elsewhere in the cell.
Editing independent effects of ADARs on the miRNA/siRNA pathways
It is shown that ADAR1 and ADAR2 have biological functions as RNA‐binding proteins that extend beyond editing per se and that even genomically encoded ADARs that are catalytically inactive may have such functions.
Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization.
- P. Silver, L. Keegan, M. Ptashne
- BiologyProceedings of the National Academy of Sciences…
- 1 October 1984
Study of intracellular compartmentalization in yeast of Escherichia coli beta-galactosidase bearing heterologous amino acid sequences at its amino terminus shows results consistent with the proposal that the GAL4 gene product mediates positive control by binding to DNA and that the information for nuclear localization resides in its aminoterminus.
dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing.
Findings show that both transcription and processing of dADAR transcripts are under strict developmental control and suggest that the process of RNA editing in Drosophila is dynamically regulated.