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Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
- E. Bochkareva, L. Kaustov, +8 authors A. Bochkarev
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 17 October 2005
One of many protein–protein interactions modulated upon DNA damage is that of the single-stranded DNA-binding protein, replication protein A (RPA), with the p53 tumor suppressor. Here we report the… Expand
Inhibition mode of a bisubstrate inhibitor of KDO8P synthase: a frequency-selective REDOR solid-state and solution NMR characterization.
- L. Kaustov, S. Kababya, V. Belakhov, T. Baasov, Y. Shoham, A. Schmidt
- Chemistry, Medicine
- Journal of the American Chemical Society
- 19 March 2003
In this report the mode of inhibition of mechanism-based inhibitor (2, K(i) = 0.4 microM) of 3-deoxy-d-manno-2-octulosonate-8-phosphate synthase (KDO8PS), which was designed to mimic the combined key… Expand
Structural and mechanistic investigation of 3-deoxy-D-manno-octulosonate-8-phosphate synthase by solid-state REDOR NMR.
15N¿(31)P¿ REDOR NMR experiments were applied to lyophilized binary complexes of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase (KDO8PS), with each of its natural substrates, phosphoenolpyruvate… Expand
Spin Transition in a Manganese(III) Porphyrin Cation Radical, Its Transformation to a Dichloromanganese(IV) Porphyrin, and Chlorination of Hydrocarbons by the Latter.
Chemical oxidation of (TMP)Mn(III)(Cl) (TMP = the tetramesitylporphyrinato dianion) by Fe(ClO(4))(3) leads to the porphyrin-oxidized product (TMP(*)(+))Mn(III)(ClO(4))(2). Magnetic measurements and… Expand
Direct Identification of Enzyme Active Site Residues by Solid-State REDOR NMR: Application to KDO8P Synthase
In this communication we report the first direct identification of active site residues of the enzyme 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase (KDO8PS). This is accomplished by the… Expand
Binding of the natural substrates and products to KDO8P synthase: 31P and 13C solution NMR characterization.
Proton decoupled 31P and 13C solution NMR experiments were applied to mixtures of 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) synthase, with each of its natural substrates, phosphoenolpyruvate… Expand
New efficient routes for the preparation of deuterated tetraarylporphyrins
Abstract Very simple and highly efficient synthetic routes for the preparation of tetraarylporphyrins, deuterated at either the β-pyrrole or the phenyl-rings, are described in this study.
Solution structure of the PHD domain of Yeast YNG2
N-terminal domain of the RPA70 subunit of human replication protein A.
Solution NMR structure of the Cbx3 in complex with H3K9me3 peptide