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Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
One of many protein–protein interactions modulated upon DNA damage is that of the single-stranded DNA-binding protein, replication protein A (RPA), with the p53 tumor suppressor. Here we report theExpand
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Inhibition mode of a bisubstrate inhibitor of KDO8P synthase: a frequency-selective REDOR solid-state and solution NMR characterization.
In this report the mode of inhibition of mechanism-based inhibitor (2, K(i) = 0.4 microM) of 3-deoxy-d-manno-2-octulosonate-8-phosphate synthase (KDO8PS), which was designed to mimic the combined keyExpand
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Structural and mechanistic investigation of 3-deoxy-D-manno-octulosonate-8-phosphate synthase by solid-state REDOR NMR.
15N¿(31)P¿ REDOR NMR experiments were applied to lyophilized binary complexes of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase (KDO8PS), with each of its natural substrates, phosphoenolpyruvateExpand
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Spin Transition in a Manganese(III) Porphyrin Cation Radical, Its Transformation to a Dichloromanganese(IV) Porphyrin, and Chlorination of Hydrocarbons by the Latter.
Chemical oxidation of (TMP)Mn(III)(Cl) (TMP = the tetramesitylporphyrinato dianion) by Fe(ClO(4))(3) leads to the porphyrin-oxidized product (TMP(*)(+))Mn(III)(ClO(4))(2). Magnetic measurements andExpand
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Direct Identification of Enzyme Active Site Residues by Solid-State REDOR NMR: Application to KDO8P Synthase
In this communication we report the first direct identification of active site residues of the enzyme 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase (KDO8PS). This is accomplished by theExpand
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Binding of the natural substrates and products to KDO8P synthase: 31P and 13C solution NMR characterization.
Proton decoupled 31P and 13C solution NMR experiments were applied to mixtures of 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) synthase, with each of its natural substrates, phosphoenolpyruvateExpand
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New efficient routes for the preparation of deuterated tetraarylporphyrins
Abstract Very simple and highly efficient synthetic routes for the preparation of tetraarylporphyrins, deuterated at either the β-pyrrole or the phenyl-rings, are described in this study.
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