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Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
TLDR
These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.
Interactive effects of subanesthetic ketamine and haloperidol in healthy humans
TLDR
Haloperidol pretreatment reduced impairments in executive cognitive functions produced by ketamine as measured by proverb interpretations and the Wisconsin Card Sorting Test, but it failed to block the capacity of ketamine to produce psychosis, perceptual changes, negative symptoms, or euphoria in healthy subjects.
Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans
TLDR
Data suggest that subhypnotic lorazepam and ketamine show a spectrum of interactive effects, ranging from antagonism to potentiation.
Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis.
TLDR
Results suggest that performance on tests of distractibility and lateralized attention are related to a measure of sensory gating, which is a key information-processing deficits in schizophrenia.
Psychiatric safety of ketamine in psychopharmacology research
TLDR
Ketamine administration at subanesthetic doses appears to present an acceptable level of risk for carefully screened populations of healthy human subjects in the context of clinical research programs that intensively monitor subjects throughout their study participation.
Coordination of Care for Homeless Individuals with Comorbid Severe Mental Disorders and Substance-Related Disorders
TLDR
It is found that care coordination is a relatively low intensity but promising intervention that may improve clinical outcomes of homeless dual-diagnosis patients.
Dose-related ethanol-like effects of the NMDA antagonist, ketamine, in recently detoxified alcoholics.
TLDR
The production of ethanol-like subjective effects by ketamine supports the potential clinical importance of NMDA receptor antagonism among the mechanisms underlying the subjective effects of ethanol in humans.
Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine
TLDR
Repeated exposure to ketamine did not result in increased behavioral responses, suggestive of behavioral sensitization, but evidence of sensitization to the behavioral effects of ketamine is not provided.
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