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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
TLDR
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time.
TLDR
This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria.
Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language.
TLDR
These patterns retain a strong signal of expansion from the Near East but also suggest that the demographic history of Europe has been complex and influenced by other major population movements, as well as by linguistic and geographic heterogeneities and the effects of drift.
Origins and divergence of the Roma (gypsies).
TLDR
Principal-components analysis and analysis of molecular variance indicate that genetic structure in extant endogamous Romani populations has been shaped by genetic drift and differential admixture and correlates with the migrational history of the Roma in Europe.
A genomic screen of autism: evidence for a multilocus etiology.
TLDR
The results suggest that positional cloning of susceptibility loci by linkage analysis may be a formidable task and that other approaches may be necessary.
Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes.
TLDR
The geographic cline of CCR5-Delta32 frequencies and its recent emergence are consistent with a historic strong selective event, driving its frequency upward in ancestral Caucasian populations.
Null mutations in LTBP2 cause primary congenital glaucoma.
From Asia to Europe: mitochondrial DNA sequence variability in Bulgarians and Turks
TLDR
Mean pairwise differences suggest that a demographic expansion occurred sequentially in the Middle East, through Turkey, to the rest of Europe (Bulgaria included), and would correspond to the arrival of anatomically modern humans in Europe.
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
TLDR
A centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls and Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.
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