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Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase.
Reactive oxygen and nitrogen species such as superoxide and nitric oxide are released into the extracellular spaces by inflammatory and airway epithelial cells. These molecules may exacerbate lungExpand
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Modulation of human β‐defensin‐1 (hBD‐1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in
hBD comprise a family of antimicrobial peptides that plays a role in bridging the innate and adaptive immune responses to infection. The expression of hBD‐2 increases upon stimulation of numerousExpand
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Vitamin D-Mediated Induction of Innate Immunity in Gingival Epithelial Cells
ABSTRACT Human gingival epithelial cells (GEC) produce peptides, such as β-defensins and the cathelicidin LL-37, that are both antimicrobial and that modulate the innate immune response. In myeloidExpand
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Inhibition of beta-defensin gene expression in airway epithelial cells by low doses of residual oil fly ash is mediated by vanadium.
Poor ambient air quality is associated with increased morbidity and mortality, including respiratory infections. However, its effects on various host-defense mechanisms are poorly understood. ThisExpand
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Mouse Model for Assessing Endotoxin Involvement in the Lung Inflammation and Cytokine Production Resulting from Inhaled Organic Dust
AbstractThe involvement of endotoxin in the development of acute pulmonary inflammation and tumor necrosis factor (TNF) release following inhalation of cotton dust was demonstrated usingExpand
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Expression of beta-defensin genes in bovine alveolar macrophages.
Bovine alveolar macrophages (BAM) were examined for the expression of beta-defensins and to determine whether their expression could be upregulated by bacterial lipopolysaccharide (LPS), as observedExpand
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Release of tumor necrosis factor in guinea pigs upon acute inhalation of cotton dust.
In guinea pigs, inhalation of cotton dust results in an acute pulmonary response with symptoms of increased breathing rate, cough, bronchoconstriction, and periods of apnea. These symptoms resembleExpand
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Alveolar macrophages from C3H/HeJ mice show sensitivity to endotoxin.
Alveolar macrophages (AM) orchestrate the release of several cytokines in the lung, including tumor necrosis factor alpha (TNF). Lipopolysaccharide endotoxin (LPS), one of the most potent stimulatorsExpand
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Exposure to Ultraviolet Radiation Enhances Mortality and Pathology Associated with Influenza Virus Infection in Mice ¶
Ultraviolet radiation (UVR) causes systemic immune suppression, decreasing the delayed type and contact hypersensitivity responses in animals and humans and enhancing certain mycobacterial, parasiticExpand
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Expression of β-Defensin Genes in Bovine Alveolar Macrophages
ABSTRACT Bovine alveolar macrophages (BAM) were examined for the expression of β-defensins and to determine whether their expression could be upregulated by bacterial lipopolysaccharide (LPS), asExpand
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