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Prevention of apoptosis by a baculovirus gene during infection of insect cells.
Programmed cell death is an active process of self destruction that is important in both the development and maintenance of multicellular animals. The molecular mechanisms controlling activation or… Expand
An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif.
Spodoptera frugiperda SF-21 cells infected with Autographa californica nuclear polyhedrosis virus mutants which lack a functional p35 gene undergo apoptosis, a type of programmed cell death. To… Expand
Control of programmed cell death by the baculovirus genes p35 and iap.
The SF-21 insect cell line undergoes rapid and widespread apoptosis when treated with actinomycin D or when infected with a mutant of the baculovirus Autographa californica nuclear polyhedrosis virus… Expand
The roles of eighteen baculovirus late expression factor genes in transcription and DNA replication.
A set of 18 plasmid subclones of the Autographa californica nuclear polyhedrosis virus genome supports expression from a late viral promoter in transient expression assays (J. W. Todd, A. L.… Expand
An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs.
Two different baculovirus genes are known to be able to block apoptosis triggered upon infection of Spodoptera frugiperda cells with p35 mutants of the insect baculovirus Autographa californica… Expand
Inhibitor of Apoptosis Proteins Physically Interact with and Block Apoptosis Induced by Drosophila Proteins HID and GRIM
ABSTRACT Reaper (RPR), HID, and GRIM activate apoptosis in cells programmed to die during Drosophila development. We have previously shown that transient overexpression of RPR in the lepidopteran… Expand
Expression and mutational analysis of the baculovirus very late factor 1 (vlf-1) gene.
We have examined the expression and function of a gene, vlf-1, of Autographa californica nuclear polyhedrosis virus that is known to encode a regulator of very late gene transcription. Western blot… Expand
Nineteen Baculovirus Open Reading Frames, Including LEF-12, Support Late Gene Expression
ABSTRACT A set of 18 plasmid subclones of the Autographa californica nuclear polyhedrosis virus genome, each containing an identified late expression factor gene (lef), supports expression from a… Expand
An exegesis of IAPs: salvation and surprises from BIR motifs.
- L. K. Miller
- Biology, Medicine
- Trends in cell biology
- 1 August 1999
The BIR (baculovirus IAP repeat) motif is a conserved sequence of approximately 70 amino acids that was identified originally in the 'inhibitor of apoptosis' (IAP) family of proteins. BIR-containing… Expand
Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs).
- D. Vucic, W. Kaiser, A. Harvey, L. K. Miller
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 16 September 1997
IAPs comprise a family of inhibitors of apoptosis found in viruses and animals. In vivo binding studies demonstrated that both baculovirus and Drosophila IAPs physically interact with an… Expand