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Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X4 Purinergic Receptors by two Complementary Methods
Background/Aims: ATP-gated P2X4 purinergic receptors (P2X4Rs) are cation channels with important roles in diverse cell types. To date, lack of specific inhibitors has hampered investigations onExpand
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Dual Effect of Acid pH on Purinergic P2X3 Receptors Depends on the Histidine 206 Residue*
Whole cell patch clamp investigations were carried out to clarify the pH sensitivity of native and recombinant P2X3 receptors. In HEK293 cells permanently transfected with human (h) P2X3 receptorsExpand
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Ethanol-induced inhibition of NMDA receptor channels
Ethanol is a potent inhibitor of the N-methyl-D-aspartate (NMDA)-receptor subtype of glutamate receptor in a number of brain areas. The mechanism of ethanol action has been investigated by means ofExpand
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Characterization of P2X3, P2Y1 and P2Y4 receptors in cultured HEK293-hP2X3 cells and their inhibition by ethanol and trichloroethanol.
Membrane currents and changes in the intracellular Ca2+ concentration ([Ca2+]i) were measured in HEK293 cells transfected with the human P2X3 receptor (HEK293-hP2X3). RT-PCR and immunocytochemistryExpand
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Interaction of P2 purinergic receptors with cellular macromolecules
Ionotropic P2X and metabotropic P2Y receptors interact with a number of macromolecules in the cell membrane which may contribute to their functional plasticity. P2X receptors are homomeric orExpand
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Regulation of Human Recombinant P2X3 Receptors by Ecto-Protein Kinase C
The whole-cell patch-clamp technique was used to record current responses to nucleotides and nucleosides in human embryonic kidney HEK293 cells transfected with the human purinergic P2X3 receptor.Expand
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P2 receptor signaling in neurons and glial cells of the central nervous system.
Purine and pyrimidine nucleotides are extracellular signaling molecules in the central nervous system (CNS) leaving the intracellular space of various CNS cell types via nonexocytotic mechanisms. InExpand
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Interaction between P2Y and NMDA receptors in layer V pyramidal neurons of the rat prefrontal cortex
In the first part of this study, monosynaptic excitatory postsynaptic potentials (EPSPs) in layer V of the rat prefrontal cortex were evoked by electrical stimulation of layer I. Recordings byExpand
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Modulation of NMDA receptor current in layer V pyramidal neurons of the rat prefrontal cortex by P2Y receptor activation.
Current responses to N-methyl-D-aspartate (NMDA) in layer V pyramidal neurons of the rat prefrontal cortex were potentiated by the P2 receptor agonists adenosine 5'-triphosphate (ATP) and uridineExpand
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Inhibition by adenosine A2A receptors of NMDA but not AMPA currents in rat neostriatal neurons
Whole‐cell patch clamp experiments were used to investigate the transduction mechanism of adenosine A2A receptors in modulating N‐methyl‐D‐aspartate (NMDA)‐induced currents in rat striatal brainExpand
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