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Distinct preference for spatial frequency content in ventral stream regions underlying the recognition of scenes, faces, bodies and other objects
Is the Retina a Mirror of the Aging Brain? Aging of Neural Retina Layers and Primary Visual Cortex Across the Lifespan
- L. Jorge, N. Canário, H. Quental, R. Bernardes, M. Castelo‐Branco
- Medicine, BiologyFrontiers in Aging Neuroscience
- 8 January 2020
An age-related decay of primary visual cortical thickness that was significantly correlated with a decrease in global and multiple layer retinal thicknesses was found and associations with other cortical regions suggest that retinal status may index cortical integrity in general.
Interplay Between Macular Retinal Changes and White Matter Integrity in Early Alzheimer’s Disease
The findings suggest that axonal damage in the brain dominates early on in this condition and shows an association with retinal structural integrity already at initial stages of AD.
The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid β Load in Early Alzheimer's Disease
A positive association between the synapse-rich inner plexiform layer (IPL) and V1 in AD is identified, which might reflect changes in synaptic function resulting from Aβ deposition, contributing to early visual loss.
Distinct mechanisms drive hemispheric lateralization of object recognition in the visual word form and fusiform face areas
Processing of performance‐matched visual object categories: faces and places are related to lower processing load in the frontoparietal executive network than other objects
- L. Jorge, N. Canário, J. Castelhano, M. Castelo‐Branco
- PsychologyThe European journal of neuroscience
- 26 March 2018
Face detection and place detection seem to be routed in specific neuronal systems that readily encode the holistic nature of this type of objects, suggesting that face/place processing does require to a much smaller extent the recruitment of the frontoparietal control network than any other object categories.
Simultaneous changes in visual acuity, cortical population receptive field size, visual field map size, and retinal thickness in healthy human aging
- Maria Fatima Silva, B. Harvey, M. Castelo‐Branco
- Medicine, BiologyBrain Structure and Function
- 10 July 2021
It is suggested that simultaneous disruptions of neural structure and function throughout the early visual system may underlie the deterioration of perceptual visual acuity in healthy aging.
Investigating the Spatial Associations Between Amyloid-β Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer’s Disease
Aβ deposition, as opposed to neuroinflammation, was more associated with cortical atrophy, suggesting a prominent role of Aβ in neurodegeneration at a mild stage of the AD.
Machine Learning Approaches in OCT: Application to Neurodegenerative Disorders
This chapter addresses the use of optical coherence tomography (OCT) to image the ocular fundus of the human eye, and the ophthalmological models of wild-type and animal models of neurodegenerative disorders.
Frontoparietal microstructural damage mediates age-dependent working memory decline in face and body information processing: Evidence for dichotomic hemispheric bias mechanisms