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Laboratory medicine best practice guideline: vitamins a, e and the carotenoids in blood.
TLDR
50 best practice recommendations represent the consensus views, in association with peer reviewed evidence of the AACB Vitamins Working Party, towards best practice for the collection, analysis and interpretation of vitamins A, E and carotenoids in blood. Expand
Identification and characterisation of Kunitz-type plasma kallikrein inhibitors unique to Oxyuranus sp. snake venoms.
TLDR
TSPI was found to be a broad spectrum inhibitor with most potent inhibitory activity observed against plasma kallikrein that corresponded to a K(i) of 0.057 ± 0.019 nM. Expand
Cloning and characterisation of novel cystatins from elapid snake venom glands.
TLDR
It is demonstrated that elapid snake venom cystatins are novel members of the type 2 family, which implies essential housekeeping or regulatory roles for these proteins in each species. Expand
Comparison of Textilinin-1 with Aprotinin as Serine Protease Inhibitors and as Antifibrinolytic Agents
TLDR
From data, textilinin-1 appears to be a more specific plasmin inhibitor than aprotinin but aProtinin inhibits clot lysis to a greater extent. Expand
Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers
TLDR
CDT has limited sensitivity as a biomarker of heavy alcohol consumption, particularly in women, patients with cirrhosis and those with an elevated BMI, so caution should be applied when ordering and interpreting %CDT results. Expand
Textilinin‐1, an alternative anti‐bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss
TLDR
Textilinin‐1, a serine protease inhibitor from Pseudonaja textilis venom with sequence relatedness to aProtinin, is a potent but reversible plasmin inhibitor and has a narrower range of protease inhibition compared to aprotinin. Expand
The structure of Human Microplasmin in Complex with Textilinin-1, an Aprotinin-like Inhibitor from the Australian Brown Snake
TLDR
The unusual mode of interaction between textil inin-1 and plasmin explains textilin in-1′s selectivity for human plasmine over plasma kallikrein and can be exploited in future drug design efforts. Expand
Reference ranges and biological variation of free and total serum indoxyl- and p-cresyl sulphate measured with a rapid UPLC fluorescence detection method.
TLDR
A robust analytical method with a short chromatography time that quantifies both IS and pCS is described and the data on reference ranges and intra-individual biological variation need to be considered in clinical studies that investigate these uremic toxins. Expand
Vitamin B1 and B6 method harmonization: comparison of performance between laboratories enrolled in the RCPA Quality Assurance Program.
TLDR
The absence of an internal standard in current vitamin B1 and B6 assays is a likely contributor to the wide dispersion of results seen in this program and kit manufacturers and laboratories are recommended to investigate the inclusion of internal standards to correct the variability that may occur during processing. Expand
BMI but not stage or etiology of nonalcoholic liver disease affects the diagnostic utility of carbohydrate-deficient transferrin.
TLDR
An elevated BMI reduces the diagnostic utility of CDT at higher alcohol intake in subjects with CLD using the standardized method, and is likely to be useful to confirm suspicion of heavy drinking in subjects who are not overweight, but cannot reliably identify moderate drinkers or heavy drinkers who are overweight. Expand
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