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Regulation of histone mRNA production and stability in serum-stimulated mouse 3T6 fibroblasts.
TLDR
The results suggest that H3 gene transcription is not tightly coupled to DNA replication but is controlled temporally during the resting to growing transition, and there is a correlation between the rate of DNA synthesis and the stability of histone H3 mRNA. Expand
Inhibition of the mammalian transcription factor LSF induces S‐phase‐dependent apoptosis by downregulating thymidylate synthase expression
TLDR
LSFdn is a novel regulatory factor that supports progression through S‐phase by targeting a single gene that is critical for cell survival by binding to sites within the TS promoter and intronic regions that are required for this induction. Expand
Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts.
TLDR
The regulation of thymidylate synthetase activity in mouse 3T6 fibroblasts during serum-induced transitions between the resting (G0) and growing state is described and indicates that the induction of gene expression was not directly coupled to DNA replication. Expand
Lack of an initiator element is responsible for multiple transcriptional initiation sites of the TATA-less mouse thymidylate synthase promoter.
TLDR
The results indicate that there are no additional promoter elements downstream of the G/C box in the initiation window of mouse thymidylate synthase and why transcription initiates across such a broad region is determined. Expand
Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts.
TLDR
The isolation and characterization of a series of 5-fluorodeoxyuridine-resistant mouse 3T6 cell lines that overproduce thymidylate synthetase (TS) by up to 50-fold compared with the parental cells are described and may serve as a convenient model system for detailed studies of the regulation of TS gene expression during the cell cycle. Expand
Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56.
TLDR
The authors' observations suggest that in mammalian cells, two UAP56-like RNA helicases are involved in splicing and nuclear export of mRNA and differential expression of these helicases may lead to quantitative or qualitative changes in mRNA expression. Expand
Splicing signals are required for S-phase regulation of the mouse thymidylate synthase gene
TLDR
It is shown that both the promoter of the mouse TS gene and TS introns are necessary (although neither is sufficient) for S-phase-specific regulation of TS mRNA content, and that the splicing reaction itself, rather than a control sequence within the intron, is important for growth-regulated expression of the TS gene. Expand
Thymidylate synthase gene expression is stimulated by some (but not all) introns.
TLDR
Analysis of minigenes that contained various combinations of introns revealed that the stimulatory effects of the introns were not additive, and almost all of intron 5 and 6 could be deleted without diminishing the stimulatories effect. Expand
Multiple protein-DNA interactions in the TATAA-less mouse thymidylate synthase promoter.
TLDR
The mouse thymidylate synthase (TS) promoter lacks a TATAA box and directs transcriptional initiation at multiple sites over a 60 nucleotide region, indicating that it is important for expression of the TS gene. Expand
Murine Cytomegalovirus Stimulates Cellular Thymidylate Synthase Gene Expression in Quiescent Cells and Requires the Enzyme for Replication
TLDR
It is shown that murine CMV infection of quiescent fibroblasts induces both mRNA and protein corresponding to the cellular thymidylate synthase (TS) gene, which encodes the enzyme that catalyzes the de novo synthesis of thymidylic acid. Expand
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