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MiR-195 suppresses the metastasis and epithelial–mesenchymal transition of hepatocellular carcinoma by inhibiting YAP
MiR-195, a novel cancer-related microRNA, was previously reported to play an important role in many malignancies. This study aimed to investigate the role of miR-195 mediated epithelial–mesenchymal… Expand
Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma
- Zenghui Liang, Y. Gao, +7 authors Z. Du
- Medicine
- TheScientificWorldJournal
- 10 October 2013
Objective. In our previous study, we found that some miRNAs were deregulated in hepatocellular carcinoma (HCC), including miR-183. However, the expression of miR-183 in the progression of benign… Expand
microRNA‐219‐5p inhibits epithelial‐mesenchymal transition and metastasis of colorectal cancer by targeting lymphoid enhancer‐binding factor 1
- Lan-Xuan Huang, C. Hu, +6 authors S. Wang
- Medicine
- Cancer science
- 29 August 2017
Aberrant expression of microRNAs (miRs) has been shown to play a critical role in the pathogenesis and progression of tumors. microRNA‐219‐5p (miR‐219‐5p) has been reported to be abnormally expressed… Expand
A population pharmacokinetic model of vancomycin for dose individualization based on serum cystatin C as a marker of renal function
- Taotao Liu, Hui-Mei Pang, +6 authors Wei-zhe Jiang
- Medicine
- The Journal of pharmacy and pharmacology
- 1 June 2019
This study aimed to establish a vancomycin population pharmacokinetics (PPK) model based on serum cystatin C and to optimize dosing for achieving targeted steady‐state trough concentrations (Css) of… Expand
Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway
- T. Wu, Min-Cong Wang, +7 authors X. Liang
- Biology, Medicine
- Drug design, development and therapy
- 14 December 2015
Resistance to cisplatin-based therapy is a major challenge in the control of lung cancer progression. However, the underlying mechanisms remain largely unclear. Autophagy is closely associated with… Expand
Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma
Abstract The aim of the study was to explore the clinical significance of let-7 expression in hepatocellular carcinoma (HCC). A PCR array was conducted to screen for let-7 expression in early-stage… Expand
Overexpression of squamous cell carcinoma antigen 1 is associated with the onset and progression of human hepatocellular carcinoma.
BACKGROUND AND AIMS
Previous studies indicated Squamous Cell Carcinoma Antigen 1 (SCCA1) may be involved in tumorigenesis and progress of various human malignancies by inhibiting cell apoptosis and… Expand
The Role of Interleukin-28b Gene Polymorphisms in Chinese Patients With Chronic Hepatitis C Treated With Pegylated Interferon and Ribavirin
Background: Interleukin-28B (IL28B) single nucleotide polymorphism (SNP) rs8099917 has been described to be associated with response to treatment with pegylated interferon and ribavirin (PEG-IFN/RBV)… Expand
BMI-1, a promising therapeutic target for human cancer.
- Min-Cong Wang, C. Li, +4 authors K. Nan
- Medicine
- Oncology letters
- 1 August 2015
BMI-1 oncogene is a member of the polycomb-group gene family and a transcriptional repressor. Overexpression of BMI-1 has been identified in various human cancer tissues and is known to be involved… Expand
Polycomb complex protein BMI-1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling, an ex vivo, in vitro, and in vivo study
- Min-Cong Wang, M. Jiao, +11 authors Chun-li Li
- Medicine
- Oncotarget
- 30 January 2016
Cancer stem cell theory indicates cancer stem cells are the key to promote tumor invasion and metastasis. Studies showed that BMI-1 could promote self-renew, differentiation and tumor formation of… Expand