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Epigallocatechin gallate promotes p53 accumulation and activity via the inhibition of MDM2-mediated p53 ubiquitination in human lung cancer cells.
Epigallocatechin gallate (EGCG), which is derived from green tea, is well known for its chemopreventive activity. Several studies have shown that p53 plays an important role in the activity of EGCG;Expand
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Increased hepcidin expression in non-small cell lung cancer tissue and serum is associated with clinical stage.
BACKGROUND Hepcidin is a small secreted peptide that plays a key role in iron metabolism. A high level of hepcidin expression may be implicated in colorectal cancer; however, the relationship betweenExpand
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Neuroepithelial transforming gene 1 functions as a potential prognostic marker for patients with non-small cell lung cancer.
Non-small cell lung cancer (NSCLC) is the most common histological cancer sub‑type worldwide. Neuroepithelial transforming gene 1 (Net-1), a Ras homolog family member A-specific guanine nucleotideExpand
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MicroRNA-138 inhibits migration and invasion of non-small cell lung cancer cells by targeting LIMK1.
MicroRNA (miR)-138 has previously been demonstrated to have a suppressive role in numerous types of human cancer, including non-small cell lung cancer (NSCLC). LIM domain kinase 1 (LIMK1) is aExpand
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Resveratrol mediates cell cycle arrest and cell death in human esophageal squamous cell carcinoma by directly targeting the EGFR signaling pathway.
Resveratrol is a small polyphenol that has been intensively studied in a wide spectrum of therapeutic fields. More recently, resveratrol has been demonstrated to exert its antitumor activity inExpand
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Sperm-associated antigen 4 (SPAG4) as a new cancer marker interacts with Nesprin3 to regulate cell migration in lung carcinoma
Lung cancer is the most common cause of cancer-related deaths, and early diagnosis and targeted therapy are extremely important in the treatment of this disease. Sperm-associated antigen 4 (SPAG4)Expand
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Krüppel‐like factor 4 promotes c‐Met amplification‐mediated gefitinib resistance in non‐small‐cell lung cancer
Gefitinib has been widely used in the first‐line treatment of advanced EGFR‐mutated non‐small‐cell lung cancer (NSCLC). However, many NSCLC patients will acquire resistance to gefitinib after 9‐14Expand
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Over-expression of protein kinase C isoforms (α, δ, θ and ζ) in squamous cervical cancer.
Protein kinase C was found to be significantly over-expressed in cancer samples compared to adjacent normal cervical tissues by proteomics in our previous study. The aim of this study was to examineExpand
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Tyrosylprotein sulfotransferase 1 expression is negatively correlated with c‑Met and lymph node metastasis in human lung cancer.
The present study aimed to test the expression of tyrosylprotein sulfotransferase 1 (TPST‑1) in human lung cancer and to analyze the correlation with clinicopathologic features and c‑Met expressionExpand
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Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis
The aim of the present study was to investigate the protective effect of eugenol on the transplanted heart and explore its mechanisms of action. Male Sprague-Dawley rats were randomly divided into aExpand
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