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Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs.
MicroRNAs (miRNAs) interact with target sites located in the 3' untranslated regions (3' UTRs) of mRNAs to downregulate their expression when the appropriate miRNA is bound to target mRNA. ToExpand
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The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo
Short hairpin RNA (shRNA)-induced RNAi is used for biological discovery and therapeutics. Dicer, whose normal role is to liberate endogenous miRNAs from their precursors, processes shRNAs intoExpand
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QTL Analysis of Yield Components in Maize under Different Environments
Maize(Zea mays L.) is one of the crops studied widely by QTL mapping. There are a lot of reports about QTL mapping for important traits,including yield components,plant height,grain moisture andExpand
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An econometric analysis of rice consumption in the People's Republic of China
Rice is the most important staple food in the People's Republic of China (PRC). In many Asian countries rice appears to have become an inferior good, with income increases leading to declines in perExpand
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Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes
  • Shuo Gu, L. Jin, +4 authors M. Kay
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 16 May 2011
MicroRNAs and siRNAs interact with target sequences in mRNAs, inducing cleavage- and non-cleavage–based gene repression through the RNA-induced silencing complex (RISC) that consists of one of fourExpand
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Slicing-Independent RISC Activation Requires the Argonaute PAZ Domain
Small RNAs regulate genetic networks through a ribonucleoprotein complex called the RNA-induced silencing complex (RISC), which, in mammals, contains at its center one of four Argonaute proteinsExpand
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The biological basis for microRNA target restriction to the 3' untranslated region in mammalian mRNAs
MicroRNAs (miRNAs) interact with target sites located in the 3′ untranslated regions (3′ UTRs) of mRNAs to downregulate their expression when the appropriate miRNA is bound to target mRNA. ToExpand
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Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice.
Hydrogen sulfide (H(2)S) is a recently discovered gasotransmitter found in mammalian tissues and blood. Treatment with H(2)S donor molecules has shown promising results in preclinical models ofExpand
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Incorporating simulation and implementation into teaching computer organization and architecture
TLDR
This paper describes the motivation, the realization, and the experience of incorporating simulation and hardware implementation into teaching computer organization and architecture to computer science students. Expand
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Improving learning effectiveness with hands-on design labs and course projects for the operating model of a pipelined processor
  • B. Hatfield, L. Jin
  • Computer Science
  • IEEE Frontiers in Education Conference (FIE)
  • 23 December 2010
TLDR
We designed and developed a series of laboratory activities that were put together into a course project for the design and implementation of an operating model of a pipelined processor. Expand
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