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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive H3K27Expand
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Managing Distributed, Shared L2 Caches through OS-Level Page Allocation
  • Sangyeun Cho, L. Jin
  • Computer Science
  • 39th Annual IEEE/ACM International Symposium on…
  • 9 December 2006
TLDR
This paper presents and studies a distributed L2 cache management approach through OS-level page allocation for future many-core processors by dynamically controlling data placement and cache sharing degrees. Expand
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Single Action Potentials and Subthreshold Electrical Events Imaged in Neurons with a Fluorescent Protein Voltage Probe
Monitoring neuronal electrical activity using fluorescent protein-based voltage sensors has been limited by small response magnitudes and slow kinetics of existing probes. Here we report theExpand
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Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients.
BACKGROUND & AIMS Recent studies have suggested that CD4(+)CD25(+) regulatory T cells (Treg) are increased and linked to compromised immune responses in patients with hepatocellular carcinoma (HCC).Expand
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Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B1
CD4+CD25+ regulatory T cells (Treg) have been shown to maintain immune tolerance against self and foreign Ags, but their role in persistent viral infection has not been well-defined. In this study,Expand
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Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients
Decompensated liver cirrhosis (LC), a life‐threatening complication of chronic liver disease, is one of the major indications for liver transplantation. Recently, mesenchymal stem cell (MSC)Expand
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Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles.
OBJECTIVE To investigate the relationship between serum P levels on the day of hCG administration and pregnancy outcomes in different responders undergoing IVF. DESIGN Retrospective study. Expand
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PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors.
The immunoreceptor PD-1 is significantly up-regulated on exhausted CD8+ T cells during chronic viral infections such as HIV-1. However, it remains unknown whether PD-1 expression on CD8+ T cellsExpand
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Use of a Self-Report-Generated Charlson Comorbidity Index for Predicting Mortality
Background:The Charlson Comorbidity Index, a popular tool for risk adjustment, often is constructed from medical record abstracts or administrative data. Limitations in both sources have fueledExpand
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Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes
SIRT3 is a major mitochondrial NAD+-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects ofExpand
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