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Interrogating a high-density SNP map for signatures of natural selection.
Identifying genomic regions that have been targets of natural selection remains one of the most important and challenging areas of research in genetics. To this end, we report an analysis of 26,530Expand
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Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation.
Recent studies suggest that haplotypes are arranged into discrete blocklike structures throughout the human genome. Here, we present an alternative haplotype block definition that assumes noExpand
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Genetic evidence supports demic diffusion of Han culture
The spread of culture and language in human populations is explained by two alternative models: the demic diffusion model, which involves mass movement of people; and the cultural diffusion model,Expand
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Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122.
The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an EastExpand
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Skin pigmentation, biogeographical ancestry and admixture mapping
Ancestry informative markers (AIMs) are genetic loci showing alleles with large frequency differences between populations. AIMs can be used to estimate biogeographical ancestry at the level of theExpand
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Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo.
CONTEXT Human follicular fluid is a combination of proteins, metabolites, and ionic compounds that is indicative of the general state of follicular metabolism and is associated with maturation andExpand
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Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina.
We analyzed admixture in samples of six different African-American populations from South Carolina: Gullah-speaking Sea Islanders in coastal South Carolina, residents of four counties in the "LowExpand
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Genomic dissection of population substructure of Han Chinese and its implication in association studies.
To date, most genome-wide association studies (GWAS) and studies of fine-scale population structure have been conducted primarily on Europeans. Han Chinese, the largest ethnic group in the world,Expand
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A genome-wide search for signals of high-altitude adaptation in Tibetans.
Genetic studies of Tibetans, an ethnic group with a long-lasting presence on the Tibetan Plateau which is known as the highest plateau in the world, may offer a unique opportunity to understand theExpand
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The dual origin and Siberian affinities of Native American Y chromosomes.
The Y chromosomes of 549 individuals from Siberia and the Americas were analyzed for 12 biallelic markers, which defined 15 haplogroups. The addition of four microsatellite markers increased theExpand
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