• Publications
  • Influence
Interrogating a high-density SNP map for signatures of natural selection.
TLDR
An analysis of single nucleotide polymorphisms with allele frequencies that were determined in three populations provides a first generation natural selection map of the human genome and provides compelling evidence that selection has shaped extant patterns of human genomic variation.
Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation.
TLDR
Through extensive coalescent simulations and analysis of published haplotype data on chromosome 21, it is found that the combined effects of population demographic history, recombination, and mutation dictate haplotype block characteristics and haplotype blocks can arise in the absence of recombination hot spots.
Genetic evidence supports demic diffusion of Han culture
TLDR
It is shown, by systematically analysing Y-chromosome and mitochondrial DNA variation in Han populations, that the pattern of the southward expansion of Han culture is consistent with the demic diffusion model, and that males played a larger role than females in this expansion.
Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122.
TLDR
It is estimated that the early northward migration of the O3-M122 lineages in East Asia occurred approximately 25,000-30,000 years ago, consistent with the fossil records of modern humans in EastAsia.
Skin pigmentation, biogeographical ancestry and admixture mapping
TLDR
This work indicates that it is possible to estimate the individual ancestry of a person based on DNA analysis with a reasonable number of well-defined genetic markers, as well as applying two methods of admixture mapping to test for the effects of three candidate genes.
Genomic dissection of population substructure of Han Chinese and its implication in association studies.
  • Shuhua Xu, X. Yin, +21 authors L. Jin
  • Biology, Medicine
    American journal of human genetics
  • 11 December 2009
TLDR
Examination of population substructures in a diverse set of over 1700 Han Chinese samples collected from 26 regions across China showed that most differentiated genes among clusters are involved in cardiac arteriopathy, and signals indicating significant differences among Han Chinese subpopulations should be carefully explained.
Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo.
TLDR
This study substantially revises the understanding of the content of human follicular fluid and lays the foundation for the future investigation of the role of miRNAs in PCOS.
Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans.
TLDR
The genetic structure of the extant southern Tibeto-Burman (STB) populations were primarily formed by two parental groups: northern immigrants and native southerners, with a bias between male and female lineages.
The dual origin and Siberian affinities of Native American Y chromosomes.
TLDR
Data suggest that Native American male lineages were derived from two major Siberian migrations, which contributed to the modern genetic pool of the Na-Dene and Amerinds of North and Central America.
Removing Batch Effects in Analysis of Expression Microarray Data: An Evaluation of Six Batch Adjustment Methods
TLDR
It is showed that it is essential to standardize expression data at the probe level when testing for correlation of expression profiles, due to a sizeable probe effect in microarray data that can inflate the correlation among replicates and unrelated samples.
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