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Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein.
TLDR
A role is established for c-fos in drug resistance and in mediating DNA synthesis and repair processes by modulating expression of genes such as dTMP synthase, DNA polymerase beta, and topoisomerase I. Expand
Reversal of the malignant phenotype by an anti-ras ribozyme.
TLDR
The results further elucidate the role of ras genes in tumorigenicity and invasion, as well as introduce ribozymes as a new class of anticancer agents. Expand
Evaluation of N-4-(hydroxycarbophenyl) retinamide as a cancer prevention agent and as a cancer chemotherapeutic agent.
TLDR
Novel strategies and mechanisms of action for retinoids in the treatment and prevention of cancer are examined in a review of retinoid analogue R11. Expand
Suppression of H-ras-mediated transformation in NIH3T3 cells by a ras ribozyme.
TLDR
The possible utility of anti-oncogene ribozymes as suppressors of tumor cell growth as well as inhibitors of cellular transformation is suggested. Expand
Effects of S86019, an active component fromPuralia lobata, on cell differentiation and cell cycle traverse of HL-60 cells
TLDR
Experimental results demonstrated that S86019 is an active inducer of cell differentiation in HL-60 cells. Expand
The utility of an anti-fos ribozyme in reversing cisplatin resistance in human carcinomas.
TLDR
The results presented here demonstrate that expression of a fos ribozyme limits Fos protein synthesis and enhances sensitivity of A2780DDP cells to antineoplastic agents, including cisplatin, and suggests their potential utility as agents to inhibit tumor cell growth. Expand
H‐ras Ribozyme‐Mediated, Alteration of the Human Melanoma Phenotype a
TLDR
The overexpression of genes encoding growth factors, their receptors, and oncogenes have all been shown to be altered as melanocytes progress into melanoma. Expand
The Role of the c-fos Oncogene in Cisplatin Resistance
The c-fos oncogene has been proposed to play an important role not only in DNA synthesis (1) but also in resistance to the antineoplastic agent cis-diamminedichloroplatinum (cisplatin) (2).Expand
Collateral sensitivity to azidothymidine in methotrexate resistant human leukemia cells.
TLDR
A 15.8-fold resistant subline, CEM/MTX, was evolved by stepwise increases in MTX exposure and was collaterally sensitive to the nucleoside analogue, azidothymidine (AZT). Expand
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