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Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373
The ATP‐gated P2X7 receptor has been shown to play a role in several inflammatory processes, making it an attractive target for anti‐inflammatory drug discovery. We have recently identified a novelExpand
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Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB 1 receptors on peripheral sympathetic nerves
1 Activation of CB1 receptors by plant cannabinoids or the endogenous ligand, anandamide, causes hypotension via a sympathoinhibitory action in anaesthetized rats. In mouse isolated vas deferens,Expand
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Identification of the amino acid residues in the extracellular domain of rat P2X7 receptor involved in functional inhibition by acidic pH
Background and purpose:  P2X7 receptors are potently inhibited by extracellular acidification. The underlying molecular basis remains unknown. This study aimed to examine the role of extracellularExpand
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The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells.
Clotrimazole (CLT) prevents dehydration of the human HbSS red cell through inhibition of Ca++-dependent (Gardos) K+ channels in vitro (1993. J. Clin Invest. 92:520-526.) and in patients (1996. J.Expand
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The influence of orally administered docosahexaenoic acid on cognitive ability in aged mice.
The purpose of this study was to investigate whether or not the role of docosahexaenoic acid (DHA) supplementation on cognitive capability was related with brain-derived neurotrophic factor (BDNF),Expand
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Pure docosahexaenoic acid can improve depression behaviors and affect HPA axis in mice.
OBJECTIVE Aim of this study was to identify whether docosahexaenoic acid (DHA) has a vital antidepressant by hypothalamic-pituitary-adrenal axis (HPA axis) or not. METHODS Mice were divided into 2Expand
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Effects of exogenous hydrogen sulfide on apoptosis proteins and oxidative stress in the hippocampus of rats undergoing heroin withdrawal
In this study, the mechanism of H2S protection in the hippocampus of heroin-treated rats was investigated. Male Sprague-Dawley rats were randomly divided into three groups: a saline group, a heroinExpand
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Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat
Abstract Context: Docosahexaenoic acid (DHA) is one of the critical fatty acids for optimal health, which affect the expression of nerve growth factor and brain-derived neurotrophic factor in brain.Expand
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Pharmacological profile of a novel cyclic AMP‐linked P2 receptor on undifferentiated HL‐60 leukemia cells
1 Extracellular ATP (EC50 = 146±57 μm) and various ATP analogues activated cyclic AMP production in undifferentiated HL‐60 cells. 2 The order of agonist potency was: ATPγS (adenosineExpand
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Effects of platelet-rich plasma on angiogenesis and osteogenesis-associated factors in rabbits with avascular necrosis of the femoral head.
  • X. Zhang, K. Shi, +6 authors L. Wang
  • Medicine
  • European review for medical and pharmacological…
  • 1 April 2018
OBJECTIVE Platelet-rich plasma (PRP) contains various growth factors and cytokines that can enhance the recovery of the damaged tissues. The present study aimed to examine the effects of PRP on theExpand
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