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α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells.
Vitamin E has long been identified as a major lipid-soluble chain-breaking antioxidant in mammals. α-Tocopherol is a vitamin E component and the major form in the human body. We propose that, besidesExpand
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Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.
PURPOSE To understand better the cell and molecular basis for the epidemiologic association between cigarette smoke, oxidant injury, and age-associated macular degeneration, the authors examined theExpand
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Bisphenol A impairs mitochondrial function in spleens of mice via oxidative stress
Increasing evidences show that bisphenol A(BPA) affects immune responses, which the mechanism is mainly regarded as estrogenic effect on a variety of immune cells. Besides its estrogenic activity,Expand
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Impairment of learning and memory induced by perinatal exposure to BPA is associated with ERα-mediated alterations of synaptic plasticity and PKC/ERK/CREB signaling pathway in offspring rats
The effect of bisphenol A (BPA) on learning and memory has attracted much attention recently, but its underlying mechanism remains unclear. We aimed to investigate whether the impairment of learningExpand
Chronic Timed Sleep Restriction Attenuates LepRb-Mediated Signaling Pathways and Circadian Clock Gene Expression in the Rat Hypothalamus
The sleep duration of adolescents has continued to decline over the past 20 years. Sleep insufficiency is one of the most important risk factors for obesity, but the mechanisms underlying theExpand
EFFECT OF SACCHAROMYCES CEREVISIAE BD101 Cu-MT ON RESISTING IRRADIATION DAMAGE IN YEAST AND MICE
The Cu-metallothionein of Saccharomyces cerevisiae BD101 can scavenge hydroxyl radicals. The yeast cells containing Cu-MT can protect against 60Coγray irradiation damage. The effects of S. cerevisiaeExpand
Abnormal differentiation of regulatory T cells and Th17 cells induced by perinatal bisphenol A exposure in female offspring mice
Background Bisphenol A (BPA) is an environmental estrogen widely exposed to human beings, and there are more studies on its reproductive toxicity, endocrine disruption and neurobehavioral disorders.Expand
Endoplasmic reticulum stress in adipose tissue at the intersection of childhood obesity-associated type 2 diabetes / insulin resistance and atherosclerosis
Childhood obesity contributing to the development of metabolic diseases is a serious public health challenge on a global scale. Abnormal or excessive fat accumulation is obvious in children who areExpand