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The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein
Cooperative interactions between Ubx protein and a divergent homeodomain protein, extradenticle (exd), that selectively increases the affinity of Ubx, but not Antp, for a particular DNA target are described. Expand
A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila.
The results suggest that phosphorylation of ANTP by CKII is important for preventing inappropriate activities of this homeotic protein during embryogenesis. Expand
Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse development.
The findings indicate that the onset of MHC class I and beta 2m gene expression in early postimplantation stage embryos is not coordinately regulated, and is consistent with results of in situ hybridization experiments showing high levels of expression of Beta 2m mRNA, and extremely weak expression of M HC class I transcripts in derivatives of the visceral endoderm in vivo. Expand
Analysis of beta 2-microglobulin gene expression in the developing mouse embryo and placenta.
In situ hybridization studies define the pattern of beta 2 m gene transcription and thus potential sites of surface expression of class I proteins in specific cell lineages in the early postimplantation stage embryo. Expand
MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon
It is demonstrated that embryonic cells in general show a defect in MHC class I assembly, and tolerance of the fetal allograft may in part be controlled at the level of peptide-dependent MHCclass I assembly. Expand
Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens.
There was no evidence to suggest that expression of the introduced H-2Dd gene affects the differentiation abilities of ES cells in vitro, and it seems likely that nonimmunological mechanisms are responsible for these prenatal lethalities. Expand