• Publications
  • Influence
The DNA sequence of the human X chromosome
The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the XExpand
  • 998
  • 58
  • PDF
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
Brain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy. Here we define the role of the most abundantExpand
  • 313
  • 17
  • PDF
Anticancer efficacy of Magainin2 and analogue peptides.
Linear helical channel-forming peptides structurally similar to the Xenopus-derived antibiotic, Magainin2-amide, were synthesized. Because activity resides in the physicochemical properties of theExpand
  • 235
  • 10
  • PDF
Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations.
Several experimental models faithfully recapitulate many important facets of human metastatic disease. Here, we have performed whole-exome sequencing in five widely used experimental metastasisExpand
  • 36
  • 3
  • PDF
Complete genome sequence of Rickettsia typhi and comparison with sequences of other rickettsiae.
Rickettsia typhi, the causative agent of murine typhus, is an obligate intracellular bacterium with a life cycle involving both vertebrate and invertebrate hosts. Here we present the complete genomeExpand
  • 208
  • 2
  • PDF
Effects of magainins on ameba and cyst stages of Acanthamoeba polyphaga.
Amebic keratitis produced by Acanthamoeba spp. is an increasingly important ocular infection in extended-use contact lens wearers. Problems associated with the infection are compounded by the lack ofExpand
  • 45
  • 2
Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine*
Background: The acyltransferase Porcupine (Porcn) is essential for active Wnt ligand production and is chemically tractable. Results: Novel small molecules targeting Porcn enables interrogation ofExpand
  • 64
  • 2
The finished DNA sequence of human chromosome 12
Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkageExpand
  • 43
  • 1
  • PDF
Treatment of urinary tract infections in hospitalized patients: a double-blind comparison of cefonicid and cefamandole.
In a randomized double-blind comparison of cefonicid (dose, 1.0 g every 24 hr) and cefmandole (dose, 1.0 g iv every 6 hr), 147 hospitalized patients (105 men, 42 women) with urinary tract infectionsExpand
  • 7
Cefonicid: an overview of clinical studies in the United States.
Cefonicid, an investigational cephalosporin with a half-life just under 5 hr, was studied by more than 100 investigators in the United States. Of 1,060 cefonicid-treated patients for whom theExpand
  • 8