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Salvia divinorum and the unique diterpene hallucinogen, Salvinorin (divinorin) A.
- L. J. Valdes
- ChemistryJournal of psychoactive drugs
- 1 July 1994
Salvia divinorum is a vision-inducing mint used by the Mazatec people of Oaxaca, Mexico. It is grown in California and other parts of the United States where it is employed as a legal hallucinogen.…
Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorum
Ethnopharmacology of ska María Pastora (Salvia divinorum, Epling and Játiva-M.).
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse
- W. Fantegrossi, Kelly M Kugle, L. J. Valdes, M. Koreeda, J. Woods
- Biology, ChemistryBehavioural pharmacology
- 1 December 2005
In the mouse, salvinorin A disrupted climbing behavior on an inverted screen task, indicating a rapid, but short-lived induction of sedation/motor incoordination and the possibility that the development of other diterpene-based opioids may yield important therapeutic compounds.
Loliolide from Salvia divinorum.
- L. J. Valdes
- Biology, MedicineJournal of natural products
Studies ofSalvia divinorum (Lamiaceae), an Hallucinogenic mint from the Sierra Mazateca in Oaxaca, Central Mexico
Experiments with material collected at different Oaxacan sites confirmed that the mint has white (rather than blue) flowers with a purple calyx and that flowering is induced by short day length.
Salvinorin C, a new neoclerodane diterpene from a bioactive fraction of the hallucinogenic Mexican mint Salvia divinorum.
Its structure was elucidated on the basis of extensive proton and C-13 NMR experiments, as well as by comparison of the NMR data with those of the mono- and diacetate derivatives 5-7 of the major NaBH(4)-reduction product of salvinorin A (2).
The absolute stereochemistry of salvinorins
The absolute stereostructures of the hallucinogenic diterpenes salvinorin A and B have been unambiguously determined by the use of the non-empirical exciton chirality circular dichroism method on…
Coleus barbatus (C.forskohlii)(Lamiaceae) and the potential new drug forskolin (Coleonol)
Chemical studies of alcoholic extracts of the tubers of C. barbatus led to isolation of the labdane diterpene forskolin (coleonol), which has become an important research tool in studying the roles of the enzyme adenylate cyclase and cyclic-AMP in cellular physiology.
An investigation of Sophora secundiflora seeds (Mescalbeans).
Chemical analysis of mescalbeans revealed the absence of detectable amounts of tryptamine derivatives; however, two additional quinolizidine alkaloids, epi-lupinine and delta5-dehydrolupanine, were isolated.