• Publications
  • Influence
Parenteral emulsions as drug carrier systems.
  • M. Singh, L. J. Ravin
  • Chemistry, Medicine
  • Journal of parenteral science and technology : a…
  • 1986
Cholesterol Solubility in Lecithin-Bile Salt Systems
The method of sample preparation can markedly influence the rate of dissolution and attainment of supersaturated states of cholesterol. The equilibrium solubility of cholesterol, studied as aExpand
Data are presented for the hydrolytic degradation of idoxuridine (5-iodo-2′-deoxyuridine) in aqueous solution over a wide range of hydrogen ion concentration (pH 1.3 to 12.0). The over-all reactionExpand
Pharmacokinetic Interpretation of Blood Levels and Urinary Excretion Data for Cefazolin and Cephalothin After Intravenous and Intramuscular Administration in Humans
Blood levels of cefazolin and cephalothin were determined in two separate crossover studies in 20 healthy male adults, each after intravenous and intramuscular administration. PharmacokineticExpand
Effect of polysorbate 80 on the solubility and in vivo availability of 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride (SK&F 33134-A).
Polysorbate 80 has been shown to have a significant effect on the solubility of 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride (SK&F 33134-A). Subsequent inExpand
Pharmacokinetic Interpretation of Cephradine Levels in Serum After Intravenous and Extravascular Administration in Humans
Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailabilityExpand
A study of the chemical stability of amphotericin B in N, N-dimethylacetamide
Abstract Studies have demonstrated the potential for using N , N -dimethylacetamide (DMA) as a solvent for solubilizing amphotericin B. The addition of sodium deoxycholate (NaDOC) to the DMA furtherExpand
Micelle formation and its relationship to solubility behavior of 2-butyl-3-benzofuranyl-4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone hydrochloride.
Micelle formation by 2-butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride was studied by conductance measurements. The CMC was approximately 0.05% and wasExpand
Chromatographic analysis of mixtures of mono-, di-, and tristearin containing mineral oil
SummaryA procedure for the quantitative separation and determination of mono-, di-, and tristearin by elution chromatography is presented. The individual components are found to be absorbed on silicaExpand
Physical-chemical evaluation of 3-(3-hydroxy-3-methylbutylamino)-5-methyl-as, triazino [5,6-b] indole (SK&F 30097).
X-ray diffraction, IR spectroscopy, and differential scanning calorimetry data are presented for the identification of two polymorphic forms and a hydrate of SKF however, Form II had a more rapidExpand