• Publications
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Cardiovascular and renal actions of dopamine: potential clinical applications.
The use of quaternary narcotic antagonists in opiate research
The current state of knowledge concerning the pharmacology of the quaternary narcotic antagonists is reviewed, their use in physiological and behavioral studies of action of opiates is examined, and guidelines for the design of experiments involving these compounds are proposed. Expand
A comparison of the vascular dopamine receptor with other dopamine receptors.
This review is concerned primarily with similari­ ties and differences in the effects of agonists and antagonists acting on the DA receptor in the canine renal vascular bed and on selected DA receptors described in other organs and species. Expand
Direct Renal Vasodilatation Produced by Dopamine in the Dog
It is suggested that the ability of dopamine to alter the distribution of cardiac output in favor of visceral organs may find useful clinical applications and the probable basis for the effect of intravenous dopamine infusion on renal blood flow is its direct renal vasodilating action. Expand
Antagonism of gut, but not central effects of morphine with quaternary narcotic antagonists.
Naltrexone methylbromide effectively antagonizes the acute gut stimulating effect, but not the chronic behavioral effect of morphine administration in dogs, and does not cross the blood-brain barrier in rats but may in mice. Expand
Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.
The results suggest that a DA receptor that is similar to the DA2 receptor is involved in the reinforcing properties of psychomotor stimulants in rhesus monkeys, and are consistent with the hypothesis that CNS DA is involvement in the reinforcement properties of Psychomotor Stimulants. Expand
Dopamine--clinical uses of an endogenous catecholamine.
  • L. I. Goldberg
  • Medicine
  • The New England journal of medicine
  • 3 October 1974
Dopamine, the immediate precursor of norepinephrine, is found in high concentrations in sympathetic regions of the immune system and has been extensively investigated in recent years. Expand
Comparison of the effects of dopamine, isoproterenol, norepinephrine and bradykinin on canine renal and femoral blood flow.
The ability of dopamine to dilate the renal vascular bed without producing a qualitatively similar direct effect on the femoral vascular bed sets it apart from agents such as papaverine and the nitrites. Expand